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Pediatric Henoch-Schonlein Purpura

What is Henoch-Schönlein purpura?

HSP is a form of vasculitis, a condition that involves inflammation of the blood vessels. It is one of the most common forms of vasculitis in childhood. HSP is seen most frequently in children between the ages of two and six years, and occurs more frequently in boys. A family connection has been noted with HSP, where the disease has happened to two or more siblings of the same family, either at the same time, or one after another.

What causes Henoch-Schönlein purpura?

As with the other forms of vasculitis, the cause of HSP is not known. HSP may be associated with an upper respiratory tract infection or possibly an allergic reaction. Most children with HSP recover completely.

What are the symptoms of Henoch-Schönlein purpura?

The following are the most common symptoms of Henoch-Schönlein purpura. However, each child may experience symptoms differently. Symptoms may include:

  • Purpura. Hemorrhage (bleeding) into the skin, mucous membranes, internal organs, and other tissues.
  • Arthralgia. Pain in the joints.
  • Inflammation of the joints
  • Abdominal pain
  • Gastrointestinal bleeding. Bleeding in the gastrointestinal, or GI, tract, which includes the mouth, esophagus, stomach, and intestines.
  • Nephritis. Inflammation of the kidneys.
  • Subcutaneous edema. Swelling just below the skin.
  • Encephalopathy. Dysfunction of the brain.
  • Orchitis. Inflammation of the testicle(s).

The symptoms of Henoch-Schönlein purpura may resemble other conditions or medical problems. Always consult your child's doctor for a diagnosis.

How is Henoch-Schönlein purpura diagnosed?

Henoch-Schönlein purpura is usually diagnosed based on a typical clinical presentation. These criteria include

  • Arthritis
  • Palpable purpura. Hemorrhage (bleeding) into the skin or mucous membranes and other tissues.
  • Abdominal pain
  • Kidney disease

If the presentation is not typical, a biopsy of the involved area may be required. In addition, ultrasound (a diagnostic imaging technique that uses high-frequency sound waves and a computer to create images of blood vessels, tissues, and organs) may be used to examine the gastrointestinal tract for presence of the disease.

Treatment for Henoch-Schönlein purpura

Specific treatment for Henoch-Schönlein purpura will be determined by your child's doctor based on:

  • Your child's overall health and medical history
  • Extent of the condition
  • Your child's tolerance for specific medications, procedures, and therapies
  • Expectation for the course of the disease
  • Specific organs that are affected
  • Your opinion or preference

Treatments for HSP may include:

  • Adequate hydration, or fluid intake
  • Careful attention to nutrition
  • Pain control with medications such as acetaminophen
  • Glucocorticoids (to control inflammation)
  • Blood pressure medication if elevated blood pressure occurs
Children's Team

Children's Team


Matthew Oetgen

Matthew Oetgen

Division Chief, Orthopaedic Surgery and Sports Medicine



The Division of Rheumatology aims to improve the health and quality of life for children with rheumatic diseases and musculoskeletal disorders through comprehensive, patient-focused care, including testing, treatment, and patient and family education programs.

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