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Pediatric Autologous Blood and Marrow Transplantation

Many patients come to the transplant(1) program at Children's National Hospital because of its excellent reputation in the field of pediatric Blood and Marrow Transplantation (BMT). Children's National patients have access to cutting-edge treatments through several clinical trials for blood and marrow transplantation. In addition, the Patient and Family Support Program provides comprehensive mental and psychosocial services and helpful resources for all patients treated in Children’s National's Center for Cancer and Blood Disorders, as well as patients’ parents and siblings.

Although Children's National oncologists refer many autologous transplant patients, Children’s National's transplant program also works with oncologists at other hospitals in the region and across the country to provide the transplant-related portion of a patient's treatment. Once that part of the treatment is complete, patients return to the care of their oncologist for either further treatment or follow-up. The transplant doctors at Children’s National remain available to treat, or help the oncologist treat, any transplant-related complications.

About Autologous Transplantation

Treatment

1.) Transplant: A medical treatment to replace a recipient’s diseased organ or tissues with a healthy organ or tissue from a donor

2.) Donor: A volunteer (related or unrelated) who has donated stem cells for a patient

3.) Chemotherapy: Treatment for cancer using chemical substances designed to kill cancer cells. It is used in large doses to help destroy a patient’s diseased marrow in preparation for a marrow transplant

4.) Neuroblastoma: A solid tumor occurring in children which, in an advanced widespread stage, may be treated by autologous stem cell transplant

5.) Bone Marrow: The spongy center of bones that is the “factory” for all blood cells in circulation

6.) White Blood Cell: Also called a “leukocyte;” a type of blood cell produced by the bone marrow to help fight infection

7.) Engraftment: Successful transplantation of donor bone marrow cells into the patient. This is shown by the growth and differentiation of donor cells to achieve normal blood counts in the recipient

8.) Viruses: A type of germ that causes infections, most of which are not effectively treated with antibiotics. Examples: cytomegalovirus (CMV), herpes, varicella (chickenpox), adenovirus, hepatitis

9.) Veno-Occlusive Disease: A rare condition which may occur in the first few weeks after a hematopoietic stem cell transplant (HSCT); caused by obstruction in the liver veins due to damage from chemotherapy and radiation

10.) Platelet: A component of the blood important in clotting. Inadequate amounts of platelets will lead to bleeding and bruising easily

11.) Red Blood Cell:  type of blood cell made in the bone marrow that carries oxygen to all parts of the body

View full glossary

Children's Team

Children's Team

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Departments

Blood and Marrow Transplant

Our blood and bone marrow disease experts provide advanced transplant procedures for children and teenagers.

Pathology and Laboratory Medicine

Whether your child needs a simple blood test or more advanced laboratory procedure, we understand it can be a frightening experience for a child and difficult for parents.

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