Research
Approximately 12 of the 36 months of training in the Pediatric Cardiology Fellowship Training Program are dedicated to research, mostly divided between the second and third years. Opportunities for clinical and basic science research are available with Children’s National faculty in Cardiology and other divisions as well as at the Children’s National Research Institute, including the Sheikh Zayed Institute for Pediatric Surgical Innovation, Washington Hospital Center, George Washington University, Georgetown University and the National Institutes of Health. In addition, fellows will have access to the new JLABS @ Washington, D.C., a 32,000-square foot facility to be located at the new Children’s National Research and Innovation Campus, which opened in 2020. This one-of-a-kind research and innovation hub will drive discoveries that save and improve the lives of children. Fellows are provided support to prepare their research for presentation at national meetings and for publication in peer-reviewed journals.
In July 2010, Children’s National was awarded the prestigious Clinical and Translational Science Award (CTSA) grant from the National Center for Advancing Translational Sciences (NCATS) to establish the Clinical and Translational Science Institute at Children’s National (CTSI-CN). This is the first and to date only such funding awarded directly to a freestanding children's hospital and recognizes the outstanding strengths in clinical and translational research. Fellows benefit from statistical support for their projects through this grant. CTSI-CN is a partnership between Children’s National and George Washington University.
Our fellows have been very successful in their academic endeavors. They routinely publish manuscripts in peer-reviewed journals and present their work at national meetings, with dozens of publications, posters and oral presentations over the last few classes. Highlights of our fellows’ recent research are included in the Cardiology Fellowship Program Overview.
Additionally, the work of our recent graduates is highlighted below.
Class of 2025 Presentations and Publications
- Surma V, Patel A, Ng D, Goswami D, Garcia A, Bembea M. Effect of Red Blood Cell Transfusion on Regional Cerebral Oxygenation in Pediatric Cardiac Surgery Patients. Anesthesia & Analgesia. Accepted for publication 2023.
Class of 2024 Presentations and Publications
- Brown K. Response to WHO Resolution - Perspectives from Global Experts and Dragons Den - Research Proposals from Emerging Scientists. 8th World Congress of Pediatric Cardiology and Cardiac Surgery. 2023. Invited speaker.
- Brown K, Roshanitabrizi P, Beaton AZ, Okello E, Rwebembera J, Linguraru M and Sable CA. Utilizing Automated Machine Learning for Rheumatic Heart Disease Detection by Doppler Echocardiography. Oral Presentation. World Congress of Cardiology/Brazil Society of Cardiology 2022. (Awarded best oral presentation).
- Brown K, Roshanitabrizi P, Beaton AZ, Okello E, Rwebembera J, Linguraru M and Sable CA. Abstract 12284: Utilizing Automated Machine Learning for Rheumatic Heart Disease Detection in Doppler Echocardiography. Poster Presentation. American Heart Association Scientific Sessions 2022.
- McLean K, Yerebakan C, Downing T, Kanter J. Hybrid stage I palliation: ductal stent comparison. Moderated poster presentation. Pediatric and Congenital Interventional Cardiovascular Society International Meeting 2023.
- Ogueri V. Congenitally Corrected TGA: From Fetus to Adulthood, Which Way Do We Go?. Presented at ACC Scientific Sessions: ACsC Scientific Session 2022; Washington, DC. 04/02/2022.
- Roshanitabrizi P, Brown K, Tompsett A, Paulli A.R., Rwebembera J, Okello E, Zühlke L, Mirabel M, Nunes M.C.P., Beaton A, Sable C, and Linguraru M.G. Analysis of Mitral Regurgitation Jet for Rheumatic Heart Disease Detection in Doppler Echocardiography. In Proc. IEEE 20th International Symposium on Biomedical Imaging (ISBI) 2023.
- Roshanitabrizi P, Roth H.R., Tompsett A, Paulli A.R., Brown K, Rwebembera J, Okello E, Beaton A, Sable C, and Linguraru M.G. Ensembled Prediction of Rheumatic Heart Disease from Ungated Doppler Echocardiography Acquired in Low-Resource Settings. In Proc. 25th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI) 2022.
- Sawda C, Henmi S, Mehta R, Haverty M, d'Udekem Y, Loke YH, Udine M. Correlation of Right Ventricular Outflow Tract Residual Disease on Post-Op Transesophageal Echocardiography and Discharge Transthoracic Echocardiography after Tetralogy of Fallot Repair. American Society of Echocardiography 34th Annual Scientific Sessions 2023.
Class of 2023 Presentations and Publications
- Choi NH, Hong J, and Moak JP. Cardioneuroablation for Pediatric Patients with Functional Sinus Node Dysfunction and Paroxysmal Atrioventricular Block. [Oral Presentation]. Heart Rhythm 2023.
- Hong J, Lewis AR, Choi NH, Ramwell CB, Barber JR, Berul CI, Sherwin ED, and Moak JP. Pacing
- Hong J, Litt SJ, Moak JP. Cardiac arrhythmias in postural tachycardia syndrome and orthostatic intolerance. Cardiol Young 2022.
- Kollar S, Balaras E, Olivieri LJ, Loke YH, Capuano F. Statistical shape modeling reveals the link between right ventricular shape, hemodynamic force, and myocardial function in repaired Tetralogy of Fallot patients. Am J Physiol Heart Circ Physiol 2022.
- Kollar SE, Klas B, Capuano F, Toro-Salazar, OH, Olivieri L, Loke, YH. Segmental Displacement is Related to Right Ventricular Remodeling and Intracardiac Vorticity in Repaired Tetralogy of Fallot Patients. ePoster Presentation at SCMR Virtual Scientific Sessions 2022.
- Kollar SE, Mandell J, Loke YH, Olivieri L. Improved Accuracy of 4D Flow with Ferumoxytol in Comparison to Gadolinium Contrast for Small Children with Congenital Heart Disease. Circulation 2021, abstract presentation.
- Kollar SE, Klas B, Toro-Salazar OH, Loke YH. Septal Segmental Displacement is Related to Decreased Exercise Capacity in Repair Tetralogy of Fallot Patients, Poster and Oral Abstract presentation at: SCMR Scientific Sessions 2023.
Kollar SE, Udine ML, Mandell JG, Cross RR, Loke YH, Olivieri LJ. Impact of ferumoxytol vs gadolinium on 4D flow cardiovascular magnetic resonance measurements in small children with congenital heart disease. J Cardiovasc Magn Reson 2022.
Kollar SE, Capuano F, Udine M, Soslow J, Loke YH, Spurney C. Decreased Left Ventricular Hemodynamic Forces as a Novel Biomarker of Myocardial Dysfunction in Duchenne Muscular Dystrophy, Poster presentation at: American Heart Association Scientific Sessions 2022.
Kollar SE, Udine M, Krishnan A, Loke YH, Ito S. Advanced Multimodality Imaging of Atrial Baffle Leak Following the Senning Operation, Poster presentation at: American Heart Association Scientific Sessions 2022.
Loke YH, Capuano F, Kollar S, Cibis M, Kitslaar P, Balaras E, Reiber JHC, Pedrizzetti G, Olivieri L. Abnormal Diastolic Hemodynamic Forces: A Link Between Right Ventricular Wall Motion, Intracardiac Flow, and Pulmonary Regurgitation in Repaired Tetralogy of Fallot. Front Cardiovasc Med 2022.
Lowrey LK, Trivedi J, Ramakrishnan K, Sinha P, Deshpande SR. Influence of Body Mass Index in Donor-Recipient Size Mismatch in Pediatric Heart Transplantation. World J Pediatr Congenit Heart Surg 2023.
Lowrey L, Trivedi J, Karthik R, Sinha P, Deshpande S. Influence of Body Mass Index in Donor Recipient Size Mismatch in Pediatric Heart Transplantation. Oral abstract presented at American College of Cardiology Scientific Sessions 2022. - Lowrey L, Trivedi J, Ramakrishnan K, Sinha P, Deshpande S. Influence of Body Mass Index in Donor Recipient Size Mismatch in Pediatric Heart Transplantation. Circulation. 2021, abstract presentation.
- Misra P. The First Step. JAMA Cardiol 2021
- Misra P. Everything We Can. Acad Pediatr 2022.
- Misra, P., Clarke, M., Lowell, F., Yurasek, G., Kind, T., Chua, I. "Getting Through the Night: Understanding ‘In-the-Moment’ Resilience of Pediatric Cardiology Fellows in the Cardiac Intensive Care Unit." Poster presentation at the Pediatric Academic Society Meeting 2023.
Class of 2022 Presentations and Publications
- Carillo ML, Levin MD, Spurney CF, Kozel BA. Global Longitudinal Strain and Longitudinal Early Diastolic Strain Rate May Identify Those Williams Syndrome Patients at Risk of Cardiomyopathy Development. Circulation. 2021, abstract presentation.
- Carillo M, Mandell J, Dham N. Supraventricular Tachyarrhythmia as a Harbinger of an Intracardiac Mass. Presented at 2020 American Academy of Pediatrics National Conference; Virtual. 10/02/2020.
- Martin GR, Schwartz BN, Hom LA, Donofrio MT. Lessons Learned from Infants with Late Detection of Critical Congenital Heart Disease. Pediatr Cardiol 2022.
- Meyers B*, Nyce J*, Zhang J, Frank LH, Balaras E, Vlachos PP, Loke YH. Intracardiac Flow Analysis of the Right Ventricle in Pediatric Patients With Repaired Tetralogy of Fallot Using a Novel Color Doppler Velocity Reconstruction. J Am Soc Echocardiogr 2023. (*Co-first authors)
- Nyce J, Meyers B, Zhang J, et al. Assessment of abnormal right ventricular vorticity in repaired Tetralogy of Fallot patients using Doppler velocity reconstruction (DOVER). J Am Coll Cardiol 2022, abstract presentation.
- Schwartz B, Hom L, Von Kohorn I, Becker J, Cuzzi S, Grier-Clarke S, Kiernan S, Martin G. Newborn Pulse Oximetry Screening at a Community Hospital: An 8-year Experience. Pediatrics 2021.
- Schwartz BN, Klein JH, Barbosa MB, Hamersley SL, Hickey KW, Ahmadzia HK, Broth RE, Pinckert TL, Sable CA, Donofrio MT, Krishnan A. Expanding Access to Fetal Telecardiology During the COVID-19 Pandemic. Telemed J E Health 2021.
- Schwartz BN, Harahsheh AS, Krishnan A, Martin GR. Cardiac Effects of COVID-19 Infection, MIS-C, and the Vaccine in Infants and Children: What Is Known and Future Implications. Am J Perinatol 2022.
- Schwartz BN, Klein JH, Barbosa MB, Hamersley SL, Hickey KW, Ahmadzia HK, Broth RE, Pinckert TL, Sable CA, Donofrio MT, Krishnan A. Expanding Access to Fetal Telecardiology During the COVID-19 Pandemic. Telemed J E Health 2021.
- Schwartz BN, Hom LA, Revenis ME, Martin GR. Rethinking Pulse Oximetry Screening in the Level-IV Neonatal Intensive Care Unit. Am J Perinatol 2022.
Class of 2021 Presentations and Publications
- Curren V, Dham N, Spurney C. Diagnosis, Prevention, Treatment and Surveillance of Anthracycline-Induced Cardiovascular Toxicity in Pediatric Cancer Survivors. Hearts 2021.
- Klein J, Donofrio MT. Fetal Echocardiography for the General Pediatrician. Pediatr Ann 2021.
- Klein JH, Beaton A, Tompsett A, Wiggs J, Sable C. Effect of anaemia on the diagnosis of rheumatic heart disease using World Heart Federation criteria. Cardiol Young 2019.
- de Loizaga SR, Arthur L, Arya B, Beckman B, Belay W, Brokamp C, Hyun Choi N, Connolly S, Dasgupta S, Dibert T, Dryer MM, Gokanapudy Hahn LR, Greene EA, Kernizan D, Khalid O, Klein J, Kobayashi R, Lahiri S, Lorenzoni RP, Otero Luna A, Marshall J, Millette T, Moore L, Muhamed B, Murali M, Parikh K, Sanyahumbi A, Shakti D, Stein E, Shah S, Wilkins H, Windom M, Wirth S, Zimmerman M, Beck AF, Ollberding N, Sable C, Beaton A. Rheumatic Heart Disease in the United States: Forgotten But Not Gone: Results of a 10 Year Multicenter Review. J Am Heart Assoc 2021.
- Scheel A, Ssinabulya I, Aliku T, Bradley-Hewitt T, Clauss A, Clauss S, Crawford L, DeWyer A, Donofrio MT, Jacobs M, Klein J, Moore TE, Okello E, Scheel J, Shaw R, Sable C, Lwabi P, Watkins DA, Beaton A. Community study to uncover the full spectrum of rheumatic heart disease in Uganda. Heart 2019.
- Ralston BH, Willett C, Namperumal S, et al. Use of Virtual Reality for Pediatric Cardiac Critical Care Simulation. Cureus 2021.
- Ralston BH, Waberski AT, Kanter JP, Schick JW, Downing TE. Measured Oxygen Consumption During Pediatric Cardiac Catheterization is More Accurate than Assumed Oxygen Consumption. Pediatr Cardiol 2023.
- Schramm J, Sivalingam S, Moreno GE, Thanh DQL, Gauvreau K, Doherty-Schmeck K, Jenkins KJ. Pulmonary Vein Stenosis: A Rare Disease with a Global Reach. Children 2021.
- Schramm J, Ito S, Frank LH, Spurney CF. Acute Chest Pain in Duchenne Muscular Dystrophy Patient With Anomalous Coronary Artery: An Etiologic Conundrum. J Am Coll Cardiol Case Rep 2021.
- Schramm J and Spurney CF. Evaluation and Management of Cardiac Complications in Neuromuscular Disorders. Book chapter in: T. Bertorini, ed. Neuromuscular Disorders: Treatment and Management. Philadelphia: Elsevier Saunders; 2021.
- Udine ML, Evans F, Burns KM, Pearson GD, Kaltman JR. Geographical variation in infant mortality due to congenital heart disease in the USA: a population-based cohort study. Lancet Child Adolesc Health 2021.
- Udine ML, Kaltman JR, Li Q, Liu J, Sun D, Cheung MC, Sabouni S, Al Dulaimi A, Sable C. Effects of blood pressure percentile, body mass index, and race on left ventricular mass in children. Cardiol Young 2022.
Class of 2020 Presentations and Publications
- Mandell JG, Christopher AB, Olivieri LJ, Loke YH. Diagnosis of a coronary sinus atrial septal defect by 4D flow MRI. Society of Cardiac Magnetic Resonance 2020.
- Mandell JG, Loke YH, Mass PN, Opfermann J, Cleveland V, Aslan S, Hibino N, Krieger A, Olivieri LJ. Aorta size mismatch predicts decreased exercise capacity in patients with successfully repaired coarctation of the aorta. J Thorac Cardiovasc Surg 2021.
- Loke YH, Capuano F, Mandell J, Cross RR, Cronin I, Mass P, Balaras E, Olivieri LJ. Abnormal Pulmonary Artery Bending Correlates With Increased Right Ventricular Afterload Following the Arterial Switch Operation. World J Pediatr Congenit Heart Surg 2019.
- Romanowicz J, Leonetti C, Dhari Z, et al. Treatment With Tetrahydrobiopterin Improves White Matter Maturation in a Mouse Model for Prenatal Hypoxia in Congenital Heart Disease. J Am Heart Assoc 2019.
- Romanowicz J, Cross R. Index of Suspicion: Supraventricular Tachycardia in a Full Term Neonate. Pediatrics in Review. 2020.
- Romanowicz J, Guerrelli D, Dhari Z, Mulvany C, Reilly M, Swift L, Vasandani N, Ramadan M, Leatherbury L, Ishibashi N, Posnack NG. Chronic perinatal hypoxia delays cardiac maturation in a mouse model for cyanotic congenital heart disease. Am J Physiol Heart Circ Physiol 2021.
- Romanowicz J, Sinha P, Donofrio MT, Schidlow DN. Predicting Cardiac Anatomy, Physiology, and Surgical Management Based on Fetal Echocardiography in Heterotaxy Syndrome. Am J Perinatol 2021.
- Voleti S, Olivieri L, Hamann K, Gordish-Dressman H, Spurney C. Troponin I Levels Correlate with Cardiac MR LGE and Native T1 Values in Duchenne Muscular Dystrophy Cardiomyopathy and Identify Early Disease Progression. Pediatr Cardiol 2020.
- Voleti S, Adelbai M, Hovis I, Colyer J, Burns KM, Lewis EO, Arurang JK, Kikuharu A, Gonzales M, Pedro SJ, Zimmerman M, Krishnan A, Beaton A, Sable C, Dougherty S. Novel handheld ultrasound technology to enhance non-expert screening for rheumatic heart disease in the Republic of Palau: A descriptive study. J Paediatr Child Health 2021.
- Voleti S, Okello E, Murali M, Sarnacki R, Majwala A, Ssembatya R, Bakka O, Namisanvu H, Njeri A, Matovu A, DeStigter K, Sable C, Beaton A. The personal and clinical impact of screen-detected maternal rheumatic heart disease in Uganda: a prospective follow up study. BMC Pregnancy Childbirth 2020.
- Voleti S, Bukhari SM, Tongut A, Yerebakan C, Ito S, Loke YH. Anomalous Right Coronary Artery off the Pulmonary Artery Strikes When You Least Expect It! CASE 2020.
Class of 2019 Presentations and Publications
- Kumthekar RN, Sumihara K, Moak JP. Pediatric radiofrequency ablation of cardiac parasympathetic ganglia to achieve vagal denervation. HeartRhythm Case Rep. 2020 Sep 14;6(11):879-883. PMID: 33204627.
- Kumthekar RN, Sinha L, Opfermann JD, Mass P, Clark BC, Yerebakan C, Berul CI. Surgical pericardial adhesions do not preclude minimally invasive epicardial pacemaker lead placement in an infant porcine model. J Cardiovasc Electrophysiol. 2020 Nov;31(11):2975-2981. PMID: 32841456.
- Kumthekar RN, Opfermann JD, Mass P, Clark BC, Moak JP, Sherwin ED, Whitman T, Marshall M, Berul CI. Percutaneous epicardial placement of a prototype miniature pacemaker under direct visualization: An infant porcine chronic survival study. Pacing Clin Electrophysiol. 2020 Jan; 43: 93-99.
- Clark BC, Kumthekar R, Mass P, Opfermann JD, Berul CI. Chronic performance of subxiphoid minimally invasive pericardial Model 20066 pacemaker lead insertion in an infant animal model. J Interv Card Electrophysiol. 2019; Oct 15.
- Kumthekar RN, Opfermann JD, Mass P, Moak JP, Sherwin ED, Whitman T, Marshall M, Berul CI. Minimally Invasive Percutaneous Epicardial Placement of a Prototype Miniature Pacemaker with Leadlet under Direct Visualization: A Feasibility Study in an Infant Porcine Model. Heart Rhythm Journal. 2019; Mar 1.
- Kumthekar R, Berul CI. Implantable Cardioverter Defibrillators and Biventricular Pacing in Pediatric Dilated Cardiomyopathy: Preventing Death and Delaying Heart Transplant. Progress in Pediatric Cardiology. Vol 49, pages 38-42, 2018.
- Mokshagundam D, Olivieri LJ, McCarter R, Kim A, Sable CA, Spurney CF, Dham N. Cardiac changes in pediatric cancer survivors. J Investig Med. 2020 Dec;68(8):1364-1369. PMID: 32868378.
- Mokshagundam D. ed. Wernovsky, G. Myocarditis. In: Pediatric Cardiology. London, UK: Elsevier; 2019: 1173-1178.
- Zimmerman M, Scheel A, DeWyer A, Nambogo JL, Otim IO, Tompsett A, Rwebembera J, Okello E, Sable C, Beaton A. Determining the Risk of Developing Rheumatic Heart Disease Following a Negative Screening Echocardiogram. Front Cardiovasc Med. 2021 Feb 12;8:632621. PMID: 33644137.
- Voleti S, Adelbai M, Hovis I, Colyer J, Burns KM, Lewis EO, Arurang JK, Kikuharu A, Gonzales M, Pedro SJ, Zimmerman M, Krishnan A, Beaton A, Sable C, Dougherty S. Novel handheld ultrasound technology to enhance non-expert screening for rheumatic heart disease in the Republic of Palau: A descriptive study. J Paediatr Child Health. 2021 Jul;57(7):1089-1095. PMID: 33624369.
- Stein E, Pulle J, Zimmerman M, Otim I, Atala J, Rwebembera J, Oyella LM, Harik N, Okello E, Sable C, Beaton A. Previous Traditional Medicine Use for Sore Throat among Children Evaluated for Rheumatic Fever in Northern Uganda. Am J Trop Med Hyg. 2020 Dec 14;104(3):842–7. PMID: 33319727.
- Scheel A, Mirabel M, Nunes MCP, Okello E, Sarnacki R, Steer AC, Engelman D, Zimmerman M, Zühlke L, Sable C, Beaton A. The inter-rater reliability and individual reviewer performance of the 2012 world heart federation guidelines for the echocardiographic diagnosis of latent rheumatic heart disease. Int J Cardiol. 2021 Apr 1;328:146-151. PMID: 33186665.
- Okello E, Ndagire E, Atala J, Bowen AC, DiFazio MP, Harik NS, Longenecker CT, Lwabi P, Murali M, Norton SA, Omara IO, Oyella LM, Parks T, Pulle J, Rwebembera J, Sarnacki RJ, Spurney CF, Stein E, Tochen L, Watkins D, Zimmerman M, Carapetis JR, Sable C, Beaton A. Active Case Finding for Rheumatic Fever in an Endemic Country. J Am Heart Assoc. 2020 Aug 4;9(15):e016053. PMID: 32750303.
- Okello E, Murali M, Rwebembera J, Atala J, Bowen AC, Harik N, Kaudha G, Kitooleko S, Longenecker C, Ndagire E, Omara IO, Oyella LM, Parks T, Pulle J, Sable C, Sarnacki R, Stein E, Zimmerman M, de Klerk N, Carapetis J, Beaton A. Cross-sectional study of population-specific streptococcal antibody titres in Uganda. Arch Dis Child. 2020 Sep;105(9):825-829. PMID: 32601082.
- Zimmerman MS, Smith AGC, Sable CA, Echko MM, Wilner LB et al. Global, regional, and national burden of congenital heart disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017 Lancet Child Adolesc Health. 2020; 4: 185-200.
- Zimmerman M, Sable C. Congenital heart disease in low-and-middle-income countries: Focus on sub-Saharan Africa. Am J Med Genet C Semin Med Genet. 2020; 184: 36-46.
- Okello E, Murali M, Rwebembera J, Zimmerman MS, et al.Cross-sectional study of population-specific streptococcal antibody titres in Uganda. Arch Dis Child. 2020