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Education & Training

  • Fellowship, Developmental-Behavioral Pediatrics, 1975
    Johns Hopkins University School of Medicine
  • Residency, Pediatrics, 1973
    University of Toronto Sunnybrook Health Sciences Center
  • MD, 1971
    University of Chicago
  • BA, Natural Science, 1967
    University of Pennsylvania

Board Certifications

  • American Board of Pediatrics
  • American Board of Pediatrics/Neurodevelopmental Disease
  • American Board of Psychiatry & Neurology

National Provider ID: 1639250442


Mark L. Batshaw, M.D., is a developmental pediatrician and Senior Investigator in the Center for Genetic Medicine Research at Children’s National Hospital. Dr. Batshaw also holds the Fight for Children Professorship in the Department of Pediatrics at the George Washington University School of Medicine & Health Sciences. He previously served as the director of the Children's National Research Institute.

He received a medical degree from the University of Chicago, completed a residency in pediatrics at the Hospital for Sick Children and a fellowship in neurodevelopmental pediatrics at the Kennedy Krieger Institute, Johns Hopkins. He previously served on the faculty of John Hopkins and the University of Pennsylvania.

Dr. Batshaw has spent his entire career caring for children with developmental disabilities. He has published more than 200 articles and reviews and is senior editor of the classic textbook, “Children With Disabilities,” now entering its eighth edition. Dr. Batshaw’s research has focused on inborn errors of urea synthesis, in which he is considered an international authority and he has been continuously funded as an National Institutes of Health Principal Investigator for over 40 years.

Research & Publications

A Pilot Study of In Vivo Liver Directed Gene Transfer With an Adenoviral Vector in Subjects with Partial Ornithine Transcarbamylase Deficiency

(2002) Gene Therapy

Brain Development and the Ontogeny of Developmental Disabilities

(2002) Advanced Pediatrics

Correction of Argininosuccinate Synthetase AS Deficiency in a Murine Model of Citrullinemia With Recombinant Adenovirus Carrying Human AS cDNA

(2000) Gene Therapy

Differences in the Human and Mouse Amino Terminal Leader Peptides of Ornithine Transcarbamylase Affect Mitochondrial Import and Efficacy of Adenoviral Vectors

(2001) Human Gene Therapy

Fatal Systemic Inflammatory Response Syndrome in a Ornithine Transcarbamylase Deficient Patient Following Adenoviral Gene Transfer

(2003) Molecular Genetics and Metabolism

Long-Term Gene Transfer to Mouse Fetuses With Recombinant Adenoviral and Adeno-Associated Virus AAV Vectors

(2000) Gene Therapy

Metabolic and Neuropsychological Phenotype in Women Heterozygous for Ornithine Transcarbamylase Deficiency

(2004) Annals of Neurology

Prospects for Prenatal Gene Therapy in Disorders Causing Mental Retardation

(2001) Mental Retardation and Developmental Disabilities Research Reviews

The Origins of Autism

(2001) Pediatric Research

Transient Depletion of CD4 Lymphocyte Improved Efficacy of Repeated Administration of Recombinant Adenovirus in the Ornithine Transcarbamylase Deficiency Sparse Fur Mice

(2000) Gene Therapy