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Genetic Disorders and Defects

Discover the conditions we treat and treatments we provide at Children's National Hospital. Providers at Children's National work with you and your family to decide on the best care plan for your child. Learn more about the Rare Disease Institute.

Deformational Plagiocephaly

Deformational plagiocephaly (flat head syndrome) is when a baby’s head develops a lasting flat spot. Learn more about this condition.

Diaphragmatic Hernia

A diaphragmatic hernia is a birth defect, which is an abnormality that occurs before birth as a fetus is forming in the mother's uterus.

Marfan Syndrome

Marfan syndrome is a disorder involving the body's connective tissue. 

Microtia

Microtia is a condition in which a child is born with an ear or ears deformed or absent.

Mosaic Down Syndrome

Mosaicism, or mosaic Down syndrome, is diagnosed when there is a mixture of two types of cells. Learn more about this condition.

Multisuture Synostosis

Learn more about the symptoms, causes and treatments for multisuture synostosis, a congenital disorder affecting brain growth and head shape.

Omphalocele

An omphalocele is a birth defect in which some of the abdominal organs protrude through an opening in the abdominal muscles in the area of the umbilical cord. A translucent membrane covers the protruding organs.

Pfeiffer Syndrome

Learn more about the symptoms, causes and treatments for Pfeiffer syndrome, a bone disorder that affects the head and face.

Phenylketonuria (PKU)

PKU is a recessive disorder which occurs in about one in 10,000 to 15,000 live births and is caused by a deficiency of the enzyme phenylalanine hydroxylase.