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About the Lab

More than 100,000 babies are born each year in the United States with structural birth defects requiring special care and interventions to survive. Despite the high incidence of these defects, finding the underlying cause in the majority of cases has been elusive. This is in part due to the complex origins of these birth defects where genetic and environmental factors interact to cause malformations. The complex etiology of birth defects makes identifying the genes involved extremely difficult. Furthermore, how susceptible genetic backgrounds interact with environmental factors to cause birth defects remains poorly understood.

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