Center for Genetic Medicine Research
About the Lab
Asthma is one of the most common chronic diseases of childhood. It disproportionately affects children of African American and Hispanic ancestry. The Pediatric Asthma Clinical and Translational Research Program at Children’s National Research Institute located in the Rastogi Lab is investigating the mechanisms that underlie asthma development and severity in minority children. Obesity, which has quadrupled in children over the past three decades, is one of the medical conditions that is associated with asthma development and severity. Since obesity-related asthma is recognized to be a form of nonallergic asthma that is poorly responsive to currently available asthma medications, the lab is focused on finding the mechanisms by which obesity is associated with asthma burden in minority children with the goal of identifying molecules for development of new therapies.
- Conrad LA, Cabana MD, Rastogi D PMID: 33173175 Pediatr Res doi: 10.1038/s41390-020-01231-6. Epub October (2020)
- Rastogi D PMID: 33097405 Paediatr Respir Rev 18:S1526-0542(20)30132-9. doi: 10.1016/j.prrv.2020.09.001 September (2020)
- Rastogi D PMID: 31912992 Pediatr Pulmonol 55(3):809-817. doi: 10.1002/ppul.24600. Epub March (2020)
De novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder populationKessler MD, Loesch DP, Perry JA, Heard-Costa NL, Taliun D, Cade BE, Wang H, Daya M, Ziniti J, Datta S, Celedón JC, Soto-Quiros ME, Avila L, Weiss ST, Barnes K, Redline SS, Vasan RS, Johnson AD, Mathias RA, Hernandez R, Wilson JG, Nickerson DA, Abecasis G, Browning SR, Zöllner S, O'Connell JR, Mitchell BD PMID: 31964835 Proc Natl Acad Sci USA 117(5):2560-2569. doi: 10.1073/pnas.1902766117. Epub February (2020)
- Rastogi D PMID: 31774320 Ann Am Thorac Soc 16(12):1497-1499. doi: 10.1513/AnnalsATS.201909-713ED December (2019)