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Center for Neuroscience Research

Ishibashi Laboratory

The Ishibashi Lab

About the Lab

Many children with congenital heart disease, particularly the most complex anomalies, suffer from important behavioral anomalies and neurodevelopmental delay after surgical correction of their anomaly. Our research activities focus on studying how congenital heart disease and subsequent cardiac surgery affect the rapidly developing brain in fetal, neonatal and infant populations. We have successfully utilized sophisticated and cutting-edge neuroscience approaches in several clinically relevant experimental models of injury. The long-term goal of our research program is to optimize treatment strategy and develop new approaches that will reduce neurodevelopmental impairment in children with congenital heart disease.
  • Lab Focus Areas

    Congenital Heart Disease and Neuroprotection

    Brain Injury, Recovery and Protection

    White matter development and function

  • Contact

    Nobuyuki Ishibashi, M.D. Director, Cardiac Surgery Research Laboratory

Featured Publications

  • Impact of mesenchymal stromal cell delivery through cardiopulmonary bypass on postnatal neurogenesis

    Maeda T, Sarkislali K, Leonetti C, Kapani N, Dhari Z, Al haj I, Ulrey R, Hanley PJ, Jonas RA, Ishibashi N PMID: 31563487 Ann Thorac Surg 109:1274-1281 April (2020)

  • Treatment with tetrahydrobiopterin improves white matter maturation in a mouse model for prenatal hypoxia in congenital heart disease

    Romanowicz J, Leonetti C, Dhari Z, Korotcova L, Ramachandra SD, Saric N, Morton PD, Bansal S, Cheema A, Gallo V, Jonas RA, Ishibashi N PMID: 31331224 J Am Heart Assoc 8(15):e012711 August (2019)

  • Cortical dysmaturation in congenital heart disease

    Leonetti C, Back SA, Gallo V, Ishibashi N PMID: 30616953 Trends Neurosci January (2019)

  • Abnormal neurogenesis and cortical growth in congenital heart disease

    Morton PD, Korotcova L, Lewis BK, Bhuvanendran S, Ramachandra SD, Zurakowski D, Zhang J, Mori S, Frank JA, Jonas, RA, Gallo V, Ishibashi N PMID: 28123074 Sci Transl Med 25;9 January (2017)

  • Microstructural alterations and oligodendrocyte dysmaturation in white matter after cardiopulmonary bypass in a juvenile porcine model

    Stinnett GR, Lin S, Korotcov AV, Korotcova L, Morton PD, Ramachandra SD, Pham A, Kumar S, Agematsu K, Zurakowski D, Wang PC, Jonas RA, Ishibashi N PMID: 28862938 J Am Heart Assoc 6(8) August (2017)
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Related News
  • Innovation District

Cell therapy research for neuroprotection in congenital heart disease receives another $3.3 million from NIH

August 18, 2023

Cell therapy research for neuroprotection in congenital heart disease receives another $3.3 million from NIH.

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