Center for Genetic Medicine Research
About the Lab
The Hahn Laboratory’s focus is understanding the impact of antimicrobial pharmacokinetics and pharmacodynamics (PK/PD) during treatment of pulmonary exacerbations in persons with cystic fibrosis, specifically on changes within the airway microbiome. We are studying microbial taxonomic diversity and functional diversity, including the impact of antimicrobial resistance. Our work published to date has revealed beta-lactam PK/PD to be an important contributor to recovery of microbial diversity after antibiotic treatment.
Airway microbial diversity is decreased in young children with cystic fibrosis compared to healthy controls but improved with CFTR modulationHahn A, Burrell A, Ansusinha E, Peng D, Chaney H, Sami I, Perez GF, Koumbourlis AC, McCarter R, Freishtat RJ, Crandall KA, Zemanick ET PubMed PMID: 32514485; PubMed Central PMCID: PMC7267737. Heliyon 6(6):e04104. doi: 10.1016/j.heliyon.2020.e04104. eCollection June (2020)
Longitudinal Associations of the Cystic Fibrosis Airway Microbiome and Volatile Metabolites: A Case StudyHahn A, Whiteson K, Davis TJ, Phan J, Sami I, Koumbourlis AC, Freishtat RJ, Crandall KA, Bean HD PubMed PMID: 32411616; PubMed Central PMCID: PMC7198769. Front Cell Infect Microbiol 10:174. doi: 10.3389/fcimb.2020.00174. eCollection (2020)
Changes in microbiome diversity following beta-lactam antibiotic treatment are associated with therapeutic versus subtherapeutic antibiotic exposure in cystic fibrosisHahn A, Fanous H, Jensen C, Chaney H, Sami I, Perez GF, Koumbourlis AC, Louie S, Bost JE, van den Anker JN, Freishtat RJ, Zemanick ET, Crandall KA PubMed PMID: 30796252; PubMed Central PMCID: PMC6385179. Sci Rep 9(1):2534. doi: 10.1038/s41598-019-38984-y February (2019)
Antibiotic multidrug resistance in the cystic fibrosis airway microbiome is associated with decreased diversityHahn A, Burrell A, Fanous H, Chaney H, Sami I, Perez GF, Koumbourlis AC, Freishtat RJ, Crandall KA PubMed PMID: 30238064; PubMed Central PMCID: PMC6143701. Heliyon 4(9):e00795. doi: 10.1016/j.heliyon.2018.e00795. eCollection September (2018)
Relationship of Pulmonary Outcomes, Microbiology, and Serum Antibiotic Concentrations in Cystic Fibrosis PatientsHahn A, Jensen C, Fanous H, Chaney H, Sami I, Perez GF, Louie S, Koumbourlis AC, Bost JE, van den Anker JN PubMed PMID: 30429692; PubMed Central PMCID: PMC6213626. J Pediatr Pharmacol Ther 23(5):379-389. doi: 10.5863/1551-6776-23.5.379 September-October (2018)