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Gropman Lab

Our Research

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Rare Disease Center Research Network: Urea Cycle Disorders Consortium (UCDC)

Neuroimaging biomarkers in UCDs

Primary Investigator

Andrea Gropman, M.D.

Co-investigators

Kuntal Sen, M.D., (neurogenetics fellow)

Matthew Whitehead, M.D.

John vanMeter, Ph.D.

EEG and subclinical seizures in patients with UCDs

Primary Investigator

Andrea Gropman, M.D.

Co-investigators

John Schreiber, M.D.

Taeun Chang, M.D.

Summary

Multimodal longitudinal imaging study using structural, fMRI, 1H MRS and DTI correlating findings with neurocognitive outcome.

This study investigates the incidence of subclinical seizures in patients with UCDs and correlates with outcome

Funding

National Institute of Child Health and Human Development (NICHD) of the National Institutes of Health (NIH) and the National Center for Advancing Translational Sciences (NCATS)

Rare Disease Center Research Network: North American Mitochondrial Disease Consortium (NAMDC)

Primary Investigator

Andrea Gropman, M.D.

Summary

Multimodal longitudinal imaging study using structural, fMRI, 1H MRS and DTI correlating findings with neurocognitive outcome.

This study investigates the incidence of subclinical seizures in patients with UCDs and correlates with outcome.

Funding

National Institute of Child Health and Human Development (NICHD) of the National Institutes of Health (NIH and National Center for Advancing Translational Sciences (NCATS)

Mito Epigen Projects:

  • MELAS
  • LHON

Primary Investigator

Anne Chiaramello, Ph.D. (GWU)

Deputy Clinical Director

Andrea Gropman, M.D.

Summary

These studies use human fibroblasts to evaluate mitochondrial bioenergetics and test small molecules for precision treatment.

Funding

NINDS/Department of Defense (DoD)

49, XXY studies: Longitudinal Study, fNIRs on Language Function

Primary Investigator

Andrea Gropman, M.D.

Summary

These studies involve neuroimaging and neuropsychology to phenotype patients with 47 XXY, 47 XYY, 48 XXXY, 48 XXYY, 49, XXXY, 47 XXX.

Funding

Philanthropy

fNIRIs Studies in Urea Cycle Disorders

Primary Investigator

Andrea Gropman, M.D.

Co-investigator

Kosar Khaksari, Ph.D.

Summary

These studies use noninvasive imaging to probe neurocognitive function in patients with UCDs.

Funding

O’Malley Family Foundation

Industry-Sponsored Studies:

  • DCA in Pyruvate dehydrogenase deficiency
  • A phase 2 safety, tolerability, pharmacokinetic and pharmacodynamic study in MELAS

Primary Investigators

Andrea Gropman, M.D.

Jeffrey Strelzik, M.D.

Summary

These studies use noninvasive imaging to probe neurocognitive function in patients with UCDs.