Center for Genetic Medicine Research
About the Lab
The Freishtat Laboratory, also known as the Intercellular Communication in Organ Injury and Repair Laboratory, investigates the role of intercellular communication at a distance in organ injury and repair. We study this communication in several diseases including asthma, diabetes, obesity, Alzheimer’s disease and sepsis. Much of this work focuses on the role of small extracellular vesicles in intercellular communication.
In infants with severe bronchiolitis: dual-transcriptomic profiling of nasopharyngeal microbiome and host responseFujiogi M, Camargo CA Jr, Bernot JP, Freishtat RJ, Harmon B, Mansbach JM, Castro-Nallar E, Perez-Losada M, Hasegawa K PubMed PMID: 31905367 Pediatr Res January (2020)
Cholesterol efflux alterations in adolescent obesity: role of adipose-derived extracellular vesical microRNAsBarberio MD, Kasselman LJ, Playford MP, Epstein SB, Renna HA, Goldberg M, DeLeon J, Voloshyna I, Barlev A, Salama M, Ferrante SC, Nadler EP, Mehta N, Reiss AB, Freishtat RJ PubMed PMID: 31331347; PubMed Central PMCID: PMC6647309. J Transl Med 17(1):232 July (2019)
Pediatric asthma comprises different phenotypic clusters with unique nasal microbiotasPérez-Losada M, Authelet KJ, Hoptay CE, Kwak C, Crandall KA, Freishtat RJ PubMed PMID: 30286807; PubMed Central PMCID: PMC6172741. Microbiome 6(1):179 October (2018)
Adipocyte-derived exosomal miRNAs: a novel mechanism for obesity-related diseaseFerrante SC, Nadler EP, Pillai DK, Hubal MJ, Wang Z, Wang JM, Gordish-Dressman H, Koeck E, Sevilla S, Wiles AA, Freishtat RJ PubMed PMID: 25518011; PubMed Central PMCID: PMC4346410. Pediatr Res 77(3):447-54 March (2015)
Platelets induce apoptosis during sepsis in a contact-dependent manner that is inhibited by GPIIb/IIIa blockadeSharron M, Hoptay CE, Wiles AA, Garvin LM, Geha M, Benton AS, Nagaraju K, Freishtat RJ PubMed PMID: 22844498; PubMed Central PMCID: PMC3406039. PLoS One 7(7):e41549 (2012)