Helix

About the Lab

The Dauber Laboratory is focused on genetic and molecular causes of undiagnosed growth disorders that lead to short stature. Short stature is the most common complaint seen by pediatric endocrinologists second only to diabetes. Most children seen for short stature remain undiagnosed and are therefore classified as having idiopathic short stature (ISS). We use current techniques such as whole exome or genome sequencing (WES/WGS), microarray analysis and targeted sequencing approaches to identify variants potentially correlated with a patient’s phenotype. Novel diagnostic methods are used to determine the functional severity of the variant, often in collaboration with multiple laboratories across the country and world.

In addition, we are interested in using bioinformatics and electronic health records to pinpoint specific undiagnosed problems that relate to growth in collaboration with the top hospitals in the United States, including Cincinnati Children’s Hospital Medical Center, Children’s Hospital of Philadelphia and Boston Children’s Hospital. Our lab also conducts novel clinical trials targeted at improving growth in children with rare genetic causes of short stature.