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Dye-free Visualization in Laparoscopy


Researchers at Children's National Hospital have developed a system for a single port laser speckle contrast image analysis in laparoscopy which offers a seamless solution to the technical difficulties associated with visualizing blood flow and tissue perfusion using current laser speckle and fluorescent imaging.


Laser Speckle Contrast Imaging (LSCI) is a non‐invasive imaging technique to visualize vascular or tissue perfusion by creating speckle patterns on the target tissue. Compared to fluorescence imaging which requires the injection of contrast agents, LSCI permits uninterrupted visualization of blood flow and tissues without the use of surgical dyes. However, current LSCI techniques require the integration of the laser light source, fiber light guide coupling and specular reflections from tissue surfaces, and the creation of multiple incisions for ideal illumination by different lights source to counter adverse effects of shadow and angle dependent uneven lights. This technology overcomes all these technical issues by providing a single port LSCI system that can be used for visualizing intraoperative perfusion, tissue viability, blood vessel identification in various organ systems (intestine, gallbladder etc.) and improve overall surgical decision making. The following are advantages of this technology:

  1. Single port used
  2. No contrast dye injection required
  3. Continuous and real‐time visualization
  4. Easily adaptable with fluorescence laparoscopy


  • Laparoscopic, endoscopic surgeries

Stage of Development

  • Preclinical validation in swine model

Intellectual Property Status

  • Patent Pending

This technology is available for exclusive or non-exclusive licensing.

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