Nikki Posnack, Ph.D.
Children’s National Heart Institute, Sheikh Zayed Institute for Pediatric Surgical Innovation: Children’s National Health System
Department of Pediatrics, Department of Pharmacology and Physiology: George Washington University, School of Medicine and Health Sciences
Ph.D., Department of Pharmacology and Physiology, George Washington University, 2009
B.S., Department of Biology, Department of Chemistry, Washington College, 2004
My research is broadly focused on how pharmacological and toxicological exposures affect cardiovascular function. Recently, our laboratory has been investigating the impact of biocompatibility and hospital-based chemical exposures (including phthalates and bisphenols) on cardiovascular health and autonomic regulation. Our laboratory also develops models to comprehensively screen medical device materials, additives and biocompatible device coatings for cardiotoxicity. Our research group is multidisciplinary, and includes individuals with expertise in cardiovascular physiology, pharmacology, toxicology and biomedical engineering. As such, our laboratory has specialized skills in cardiovascular models (neonatal and adult myocytes, human stem cell-derived myocytes, ex vivo perfused hearts, in vivo radiotelemetry, induced pluripotent stem cells), electrophysiology, imaging modalities (confocal, optical mapping, optical spectroscopy) and phenotypic assays (metabolic, gene expression arrays, calcium and voltage dyes).
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