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Image-Guided Planning System for Skull Correction in Children with Craniosynostosis

Key Personnel

  • Marius George Linguraru, DPhil 
  • Gary Rogers, MD 
  • Benjamin Wood, MD 
  • Andinet Enquobahrie, PhD, Kitware, Inc.

Craniosynostosis is the premature fusion of cranial sutures and occurs in approximately one in 2,000 live births. It results in cranial malformation that can lead to elevated intra-cranial pressure, brain growth impairment, and developmental deficiency. The most common treatment option for craniosynostosis is surgery. However, the surgical treatment planning of craniosynostosis is currently qualitative, subjective, and irreproducible, and the remodeling of the cranial vault is guided solely by the surgeon’s experience.

To address these challenges, we have created a software technology for treatment planning and evaluation of craniosynostosis through quantitative, robust, accurate, and reproducible methods to assess cranial shape. The potential impact of our technology is reduced perioperative morbidity and lower treatment costs. The technology will also enable the precise, quantitative comparison of measurements before and after cranial vault reconstruction to determine the efficacy and durability of specific reconstructive techniques. At this stage, we have developed the first generation of a software technology for comprehensive cranial shape analysis and obtained positive bench tests for the accurate diagnosis of metopic craniosynostosis. At the next stage, we will develop and evaluate a software planning system for cranial remodeling. The project is a coordinated effort between Children’s National Hospital and Kitware, Inc.