IGNITE: Safety and Feasibility of MR-HIFU Ablation of Osteoid Osteoma

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Key Personnel

  • Karun Sharma, MD, PhD 
  • Pavel Yarmolenko, PhD 
  • Haydar Celik, PhD 
  • Aerang Kim, MD, PhD 
  • Peter Kim, MD, PhD

Synopsis
Osteoid osteoma (OO) is a benign, but painful bone tumor commonly occurring in children and young adults. Common treatment options are surgical excision, or more recently, CT-guided radio frequency ablation (RFA). RFA is less invasive, but it still requires drilling from the skin through muscle and soft tissue into bone. It also exposes the patient and operator to ionizing radiation.

Magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) provides precise and controlled delivery of focused ultrasound energy inside a lesion using an external applicator, without the need for a scalpel or needle. MR-HIFU has been successfully used to treat painful bone metastases in adult clinical trials and one recent report suggests that it can also be used to treat OO. MR-HIFU ablation of OO may provide a better alternative to surgical resection or RFA as it is completely non-invasive and does not require ionizing radiation. These two qualities of MR-HIFU are especially beneficial in growing children and young adults.

Findings / Accomplishments
Our team treated the first OO patient in the USA using MR-HIFU and continues to recruit patients.

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