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The Children's National Research Institute


Neocortical Development

Tyler, WA, Medalla, M., Guillamon-Vivancos, T., Luebke, J.I. and Haydar, T.F. (2015) Neural precursor lineages specify distinct neocortical pyramidal neuron types. Journal of Neuroscience, 35(15):6142-52.

Dillon, G.M.*, Tyler, W.A.*, Omuro, K.C., Kambouris, J., Tyminski, C., Henry, S., Haydar, T.F., Beffert, U., Ho, A., (2017) CLASP2 links Reelin to the cytoskeleton during neocortical development. Neuron, 93(6): 1344-1358. *, co-first authors.

Guillamon-Vivancos, T., Tyler, W.A., Medalla, M., Chang, W.W., Okamoto, M., Haydar, T.F.* and Luebke, J.I.* (2019) Distinct neocortical progenitor lineages fine-tune neuronal diversity in a layer-specific manner. Cerebral Cortex, Mar 1, 29(3):1121-1138. * Co-corresponding authors.

Li, Z., Tyler, W.A. and Haydar, T.F. (2020) Lessons from single cell sequencing in CNS cell specification and function. Curr. Opin. Genet. Dev. Jul 14;65:138-143.

Li, Z*., Tyler, W.A.,* Zeldich, E., Santpere Baro, G., Okamoto, M., Gao, T., Li, M., Sestan, N.† and Haydar T.F. † (2020) Transcriptional priming as a conserved mechanism of lineage diversification in the developing mouse and human neocortex. Sci. Adv. 6(45):eabd2068. doi: 10.1126/sciadv.abd2068. Print 2020 Nov. *co-first authors, †corresponding authors.

Down Syndrome Brain Development

Olmos-Serrano, J.L.1, Kang, H.J.1, Tyler, W.A.1, Cheng, F.1, Zhu, Y., Silbereis, J.C., Pletikos, M., Jankovic-Rapan, L., Cramer, N.P., Galdzicki, Z., Goodliffe, J., Peters, A., Sethares, C., Haydar, T.F.* and Sestan, N.* (2016) Down syndrome developmental brain transcriptome reveals defective oligodendrocyte differentiation and myelination. Neuron, 89: 1-15. 1, co-first authors; *, co-corresponding authors.

Olmos-Serrano, J.L., Tyler, W.A, Cabral, H.J. and Haydar, T.F. (2106) Longitudinal measures of cognition in the Ts65Dn mouse: Refining windows and defining modalities for therapeutic intervention in Down syndrome. Exp. Neurol. 279:40-56.

Goodliffe, J.W., Olmos-Serrano, J.L., Aziz, N.M., Pennings, J.L., Guedj, F., Bianchi, D.W. and Haydar, T.F. (2016) Absence of prenatal forebrain defects in the Dp(16)1Yey/+ mouse model of Down syndrome. Journal of Neuroscience 36(10):2926-44.

Aziz, N.M., Guedj, F. Pennings, J.L.A., Olmos-Serrano, J.L., Seigel A., Haydar, T.F.* and Bianchi, D.W.* (2018) Lifespan analysis of brain development, gene expression and behavioral phenotypes in the Ts1Cje, Ts65Dn and Dp(16)1/Yey mouse models of Down syndrome. Dis Model Mech Jun 12, 11(6) pii: dmm031013. doi: 10.1242/dmm.031013. * Co-corresponding authors.

Aziz, N.M., Klein, J.A., Brady, M.R., Olmos-Serrano, J.L., Gallo, V. and Haydar, T.F. (2019) Spatiotemporal development of spinal neuronal and glial populations in the Ts65Dn mouse model of Down syndrome. J. Neurodev. Disord. Dec 16, 11(1): 35. doi: 10.1186/s11689-019-9294-9.

Haydar, T.F. (2020) Neurogenesis, Myelination, and Circuitry: The Case for a Distributed Therapeutic Regimen in Down Syndrome. Am. J. Intellect. Dev. Disabil. 125(2):100-102.

Shaw, P.R., Klein, J.A., Aziz, N.M. and Haydar T.F. (2020) Longitudinal neuroanatomical and behavioral analyses show phenotypic drift and variability in the Ts65Dn mouse model of Down syndrome. Dis. Model. Mech. 2020 Aug 17:dmm.046243. doi:10.1242/dmm.046243.