The Children's Research Institute
Neonatal Neurocritical Care Research Program
The NNCC Research Program focus on clinical research aimed to advance neuroprotective care in the Neonatal Intensive Care Unit (NICU). Our goal is to optimize neurodevelopmental outcomes in preterm and high-risk term newborns through improving neurodiagnostics and neurotherapeutic interventions. Research spans 1) preclinical work led by Dr. Joseph Scafidi to develop novel therapeutics in animal models of developmental brain injury; 2) clinical investigations led by Dr. An Massaro to establish blood-based, physiological and imaging biomarkers of neonatal brain injury; 3) technology development led by Dr. Tammy Tsuchida to advance neuromonitoring capabilities in the intensive care unit environment; and 4) therapeutic trials led by Dr. Taeun Chang to evaluate neuroprotective therapies such as erythropoietin in newborns with hypoxic ischemic encephalopathy. Other important areas of research focus include the role of the placenta in the development of perinatal brain injury and understanding the risk factors, treatment, and outcomes of neonatal seizures.
An Masaro, MD
Taeun Chang, MD
Joseph Scafidi, DO
Tammy Tsuchida, MD, PhD
Advanced Pediatric Brain Imaging Laboratory
Fetal and Translational Medicine
Anna Penn Laboratory
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