Funding

Current Funding

R01/R56HL141237, NIH, NHLBI
Nino, Gustavo (PI) TSLP RESPONSES IN THE HUMAN INFANT AIRWAY EPITHELIUM AND RECURRENT WHEEZING AFTER RV AND RSV INFECTION
Role: Principal Investigator
Our central hypothesis is that during infancy the human airway epithelium has enhanced TSLP responses to RV or RSV infections and to define the role of IL1β and NF-kB signaling in mediating developmental differences in TSLP production in human infant vs. adult AECs.

R21AI130502, NIH, NIAID
Nino, Gustavo (PI) EXOSOMAL MIR-155 REGULATES AIRWAY EPITHELIAL IMMUNE RESPONSES IN INFANTS WITH RHINOVIRUS INFECTION
Role: Principal Investigator
Our central hypothesis is that exosomal miR-155 increases IFN responses in the nasal AEC of infants and enhances their airway antiviral immunity during RV infection. Using in vivo and in vitro human-based approaches, in this project we will define the exosomal miR-155 response during RV infection in infants, determine its association with clinical disease, and establish the effects of exogenous miR-155 therapy in infant-derived nasal AECs during RV infection.

5669, NIH, NHLBI
Linguraru, Marius/ Enquobahrie, Andinet / Nino, Gustavo (MPI) IMAGING BIOMARKERS OF SEVERE RESPIRATORY INFECTIONS IN PREMATURE INFANTS
Role: Principal Investigator
Our goal is to develop an objective imaging biomarker framework to assess the risk of severe respiratory disease in premature babies using non-invasive low-radiation X-ray imaging software technology. Specifically, in this project we will correlate clinical respiratory outcomes with computer-based quantification of air trapping and irregular opacities (LungAIR software) in CXR images from premature infants.

Completed Funding

NIH, NICHD K12HD001399
NIH, NCATS UL1TR000075
NIH, NHLBI  K12HL090020
Board of Visitors Grant, Children's National Hospital