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The Children's National Research Institute

Funding

Current Funding

Margaret Q. Landenberger Foundation Research Award, Margaret Q. Landenberger Foundation
Sub-therapeutic Antibiotic Exposure Leads to Pathogen Dominance in the Cystic Fibrosis Airway

The goals of the study are to 1) determine the effect of β-lactam antibiotic PD indices on the changes in pediatric airway microbiome taxonomic and functional diversity, 2) determine the effect of antibiotic spectrum of activity on changes in pediatric airway microbiome taxonomic and functional diversity, and 3) determine if β-lactam antibiotic resistance is associated with airway microbiome taxonomic diversity and the presence of Prevotella.
3/1/2017 - 2/28/2019
Role: PI

Harry Shwachman Clinical Investigator Award, Cystic Fibrosis Foundation
Sub-therapeutic Antibiotic Pharmacokinetics Impact the CF Airway Microbiome

The goals of the study are to 1) determine the association between sub-therapeutic β-lactam T>MIC and airway microbiome taxonomic diversity, 2) determine the association between broader antibiotic spectrum use and airway microbiome taxonomic diversity, and 3) evaluate the concerted association between β-lactam T>MIC and antibiotic spectrum on pulmonary function.
4/1/2018 - 3/31/2021
Role: PI

Past Funding

  • Board of Visitors Grant Program, Board of Visitors at Children’s National
    Comparison of airway microbiome diversity in young children with cystic fibrosis to unaffected controls of similar age
    The goals and objectives of this study are to determine if we can improve management of CF in infants and young children by offering a non-invasive way to monitor those at risk for disease progression using the microbial signature detected in throat swabs to potentially slow their loss of lung function related to undiagnosed infections.
    Role: PI
  • 1K12HL119994-02 (Freishtat), NIH/NHLBI
    Integration of clinical pharmacology of antibiotics with metagenomic approaches to the lung microbiome to optimize treatment in pediatric lung infections in cystic fibrosis
    The goal of this study is to identify patterns of changes in lung microbiome diversity in relation to antibiotic exposure for pulmonary exacerbations in children with cystic fibrosis.
    Role: K12 Scholar
  • Clark Charitable Foundation, Clark Charitable Trust 
    Creation of a Biorepository for Respiratory Samples from the Cystic Fibrosis Population
    The goal of this project is to create a biorepository of respiratory samples of children and adults with cystic fibrosis that can be used for future studies, including those outlined in my K23 Career Development Award.
    Role: PI
  • NIH Loan Repayment Program, NIH/NIAID
    Integration of clinical pharmacology of antibiotics with metagenomic approaches to the lung microbiome to optimize treatment in pediatric lung infections in cystic fibrosis
    The goal of this study is to identify patterns of changes in lung microbiome diversity in relation to antibiotic exposure for pulmonary exacerbations in children with cystic fibrosis.
    Role: PI
  • CTSI Voucher Award, CTSI-Children’s National
    Metagenomic evaluation of the lung microbiome with antibiotic treatment in cystic fibrosis
    The goal of this project is to identify patterns of changes in lung microbiome diversity in relation to antibiotic exposure for pulmonary exacerbations in children with cystic fibrosis. These funds were set aside to conduct next generation sequencing.
    Role: PI
  • President’s Award for Innovative Research, Children’s Research Institute
    Metagenomic evaluation of the lung microbiome with antibiotic treatment in cystic fibrosis
    The goal of this project is to identify patterns of changes in lung microbiome diversity in relation to antibiotic exposure for pulmonary exacerbations in children with cystic fibrosis. This was a competitive Children's National junior faculty award. These funds were set aside to conduct pharmacokinetic analyses.
    Role: PI

  • NIH Loan Repayment Program, NIH/NIAID
    Integration of clinical pharmacology of antibiotics with metagenomic approaches to the lung microbiome to optimize treatment in pediatric lung infections in cystic fibrosis
    The goal of this study is to identify patterns of changes in lung microbiome diversity in relation to antibiotic exposure for pulmonary exacerbations in children with cystic fibrosis.
    Role: PI

  • NIH Loan Repayment Program, NIH/NIAID
    Pharmacogenomics of β-Lactam Induced Neutropenia
    The goal of this study was to identify the molecular mechanisms behind a common adverse effect of antibiotics, beta-lactam induced neutropenia.
    Role: PI
  • T32HD069054 (Vinks), NIH/NICHD
    Pharmacogenomics of β-Lactam Induced Neutropenia
    The goal of this study was to identify the molecular mechanisms behind a common adverse effect of antibiotics, beta-lactam induced neutropenia.
    Role: T32 Trainee