Led by Brian Rood, M.D., our laboratory is working to apply the tools of cutting edge quantitative proteomics to discover the functional biology of childhood brain tumors. Our findings indicate that disease-specific proteins detected in medulloblastoma tumor cells and cerebrospinal fluid can provide biological insight into the disease and identify critical biomarkers—measurable indicators of the presence or biological characteristics of the disease. Further, therapeutic targets are most often proteins, and thus proteomics offers a promising platform for drug and immunotherapy target identification. 

Representative publications:

Staal, J., Lau, L., Zhang, H., Ingram, W., Hallahan, A., Northcott, P., Pfister, S., Wechsler-Reya, R., Rusert, J., Taylor, M., Cho, Y., Packer, R., Brown, K., Rood, BR. (2015). Proteomic profiling of high risk medulloblastoma reveals functional biology. Oncotarget, 5. May 2015.

Karunasena E, McIver LJ, Rood BR, Wu X, Zhu H, Bavarva JH, Garner HR. Somatic Intronic Microsatellite Loci Differentiate Glioblastoma from Lower-Grade Gliomas. Oncotarget. 2014 Aug 15;5(15):6003-14. PMID: 25153720

Saratsis AM, Yadavilli S, Magge S, Rood BR, Perez J, Hill A, Hwang E, Kilburn L, Packer RJ, Nazarian J. Insights into pediatric diffuse intrinsic pontine glioma through proteomic analysis of cerebrospinal fluid. Neuro-Oncol 2012 May;14(5):547-60. (PMCID: PMC3337313)

Rajagopal MU, Hathout Y, MacDonald TJ, Kieran MW, Gururangan S, Blaney SM, Philips P, Packer R, Gordish-Dressman H, Rood BR. Proteomic profiling of cerebrospinal fluid identifies prostaglandin D2 synthase as a putative biomarker for pediatric medulloblastoma: A Pediatric Brain Tumor Consortium Study. Proteomics 2011 Mar;11(5):935-43. (PMCID: PMC3088509)

Van Rechem C*, Rood BR*, Touka M*, Pinte S*, Jenal M, Guerardel C, Ramsey K, Monte D, Begue A, Tschan M, Stephan D, Leprince D. Scavenger chemokine (CXC motif) receptor 7 (CXCR7) is a direct target gene of HIC1 (Hypermethylated In Cancer 1). J Biol Chem 2009 Jul 31; 284(31):20927-35. (PMCID: PMC2742858) *equal first authors

Rood BR. Zhang HZ, Cogen PH. Inter-cellular heterogeneity of expression of the MGMT DNA repair gene in pediatric medulloblastoma. Neuro-Oncol 2004 Jul; 6(3): 200-7.

Rood BR, Zhang HZ, Weitman DM, Cogen PH. Hypermethylation of HIC-1 and 17p allelic loss in medulloblastoma. Cancer Res 2002;62:3794-7.