Nikki Posnack, Ph.D., investigates the impact of environmental influences on cardiovascular function. Specifically, her recent work focused on how endocrine disrupting chemicals, which are used in the manufacturing of medical devices and consumer products, can alter cardiac electrical and mechanical function. Dr. Posnack's laboratory collaborates on a number of clinically-relevant projects that aim to improve patient outcomes following cardiac surgery and/or transfusion procedures. The laboratory utilizes a wide-array of cardiovascular models (neonatal cardiac cells, human stem cell-derived myocytes, whole hearts, in vivo radiotelemetry), imaging modalities (confocal, optical mapping, hyperspectral), and phenotypic assays (metabolic, gene expression arrays, calcium and voltage dyes). Dr. Posnack's laboratory is part of the Children's National Heart Institute and the Sheikh Zayed Institute for Pediatric Surgical Innovation.