Taeun Chang, MD, is a neurologist in the division of Neurophysiology, Epilepsy, and Critical Care at Children's National Health System. She also serves as the Director of the Neonatal Neurology and Neonatal Neurocritical Care Program.
Dr. Chang was raised and primarily educated in the Washington, DC, metropolitan area. Her interest in neuroscience and medicine began when she attended the Montgomery Blair High School Magnet Program for Math, Science & Computer Science and continued on through M.I.T. spending summers conducting research with a neurosurgeon at Children’s National, and George Washington University School of Medicine when she decided to pursue Child Neurology. She completed her pediatric residency at Children’s Hospital of Pittsburgh before returning to Children’s National for her child neurology fellowship.
As director of the Neonatal Neurology and Neonatal Neurocritical Care Program, Dr. Chang’s goals are to expand and support clinical & basic science research in neonatal brain injuries and neonatal neurotherapeutics. Dr, Chang successfully created a neonatal neurocritical care (NNCC) service and an outpatient neonatal neurology clinic program in 2004. The NNCC service is composed of 3 dedicated neonatal neurologists and is consulted on over 250 infants each year in our 54-bed state-of-the-art Level IV NICU (one-third of all NICU admissions). In conjunction with the NICU, Dr. Chang established Children’s National’s neonatal cooling protocol & program in 2006. Children’s National has cooled over 280 newborns to date. More recently, Dr. Chang was the Principal Investigator for Children’s National serving as an enrolling center in both the Phase I/II and Phase II clinical trial for Erythropoeitin as a neuroprotective agent in neonates led by UCSF (Dr. Yvonne Wu).
Drs. Chang and Tammy N. Tsuchida have established an internationally-renown neonatal neuromonitoring unit with 4 digital video EEG monitors in the NICU and bedside remote EEG access to each NICU bed. The NNCC service performs more than 400 prolonged continuous video-EEGs per year in our NICU (over 2000 continuous EEG recordings since 2006); identifies more than 50 newborns per year with seizures as a result of hypoxic ischemic encephalopathy, perinatal strokes, cerebral dysgenesis, infection, inborn errors of metabolism or infantile epilepsy disorders; led national committees to establish neonatal EEG monitoring guidelines and terminologies; and collaborates on multiple national study groups for neonatal EEG, seizures and seizure treatment trials.
Dr. Chang and her colleagues in Neurology, Neonatology, Neuroradiology and Fetal Neurology are working on advancing the frontiers of neonatal neurointensive care and examining the antecedents for their brain injury or malformations. This age group has been largely ignored for neurologic therapies but is the leading age group for cerebral palsy and neurodevelopmental sequelae, a growing burden on society in general. Members of the program are actively involved in understanding the types and causes of neurologic injury in premature and term newborns, establishing clinical guidelines and pathways, promoting neonatal neuroprotective treatments, and advancing the frontiers of this new subspecialty within child neurology.
Research & Publications
Research & Publications
Controlling chaos in the brain
Detecting dynamical interdependence and generalized synchrony through mutual prediction in a neural ensemble
(1996) Physical Review E
Discriminating deterministic versus stochastic dynamics in neuronal activity
(1994) Integrative Physiological & Behavioral Science
Fluctuations of excitability in the monosynaptic reflex pathway to lumbar motoneurons in the cat
(1994) Journal of Neurophysiology
Pseudotumor Cerebri in Children with Sickle Cell Disease A Case Series
Stochastic versus deterministic variability in simple neuronal circuits I Monosynaptic spinal cord reflexes
(1994) Stochastic versus deterministic variability in simple neuronal circuits I. Monosynaptic spinal cord reflexes.
Tests for nonlinearity in short stationary time series
The influence of electric fields on the epileptiform bursts induced by high potassium in CA3 region of the rat hippocampal slice
(1998) Neurological Research
View publications on PubMed