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Mary Donofrio, MD

Cardiologist | Director, Fetal Heart Program | Co-Director, Cardiac Neurodevelopmental Outcome Program
Awards and Recognition:
    Top Doctors
    No. Va. Magazine
    (2015, 2016, 2017, 2018)


Languages Spoken

  • English


Board Certifications

  • American Board of Pediatrics/Pediatric Cardiology

National Provider ID: 1386704633



Mary Donofrio is a national expert in fetal cardiology and has published over 90 papers, including the American Heart Association Scientific Statement on the Diagnosis and Treatment of Fetal Cardiac Disease. She is one of the founders and current president of the Fetal Heart Society, a non-profit organization created to advance the art and science of fetal cardiovascular medicine, improve the understanding of in-utero cardiovascular physiology by fostering scientific research, organized research collaboration, and mentorship, and educate medical and research professionals through scientific publications, education and meetings.

Education & Training

Education & Training

  • Fellowship Program, Pediatric Cardiology, 1995
    Children's Hospital of Philadelphia
  • Residency Program, Pediatrics, 1992
    Cornell New York Hospital
  • Internship Program, Pediatrics, 1990
    Cornell New York Hospital
  • MD, 1989
    Mount Sinai School of Medicine
  • BA, 1985
    Johns Hopkins University
Patient Stories

Patient Stories: Mary Donofrio


Sophia's Story

During a routine 20-week prenatal ultrasound, Carol Kando-Pineda’s obstetrician in Fredericksburg, Virginia, spotted abnormalities in Carol’s unborn child that she referred to as “possibly inconsistent with life.”

Ryan M

Ryan's Story

Ryan was born with a rare condition -- his heart developed outside his body. Find out how Children's doctors worked together to help Ryan thrive.

conjoined twins

Tyson and Tyler's Story

Before they had even entered the world, Children's National doctors had hatched a plan to safely deliver and then separate conjoined twins Tyson and Tyler.

xiomara teaser 2

Xiomara's Story

When Xiomara's mother Elena was 20 weeks pregnant, her ultrasound uncovered something that didn’t look right. Elena was referred to Children’s National Health System to meet with Mary Donofrio, MD, in the Fetal Heart Program who flagged a few potential heart issues and continued to monitor Xiomara throughout the remainder of the pregnancy.


Gino's Story

When Dieana was getting her 19-week obstetrical ultrasound, she got some unsettling news about her son, Gino.



Advanced MRI can detect placental perfusion abnormalities in pregnancies complicated by fetal CHD

In pregnancies complicated by fetal congenital heart disease, global placental perfusion was significantly decreased and regional variation of placental perfusion significantly increased as pregnancies progressed, findings that point to non-invasive imaging providing an early warning of placental dysfunction. A Children’s National Health System research team is thought to be the first to report non-invasive, whole placenta perfusion imaging in utero in a study published online Nov. 23, 2017 in Scientific Reports.

Getting to the Heart of Cardiac Malposition With Fetal MRI

In a small percentage of pregnancies, the fetuses’ hearts develop in the wrong place. In the congenital anomaly known as heterotaxy syndrome that often includes a severe heart defect, the heart is often displaced from its usual position in the left chest.

headshot of Mary Donofrio

Fetal Risk-Assessment Protocol Developed at Children’s National Predicts Complications from Congenital Heart Disease at Birth

Mary T. Donofrio, MD, Director of the Fetal Heart Program and Critical Care Delivery Program at Children’s National, has published the conclusions of an eight-year study determining the accuracy of a delivery room risk-assessment ranking protocol for babies diagnosed in utero with congenital heart disease (CHD), in the Journal of the American Society of Echocardiography. 

Research & Publications

Research & Publications

ACCFAHAAAP Recommendations for Training in Pediatric Cardiology Task Force 2 Pediatric Training Guidelines for Noninvasive Cardiac Imaging

(2005) Journal of the American College of Cardiology

Autoregulation of Cerebral Blood Flow in Fetuses with Congenital Heart Disease The Brain Sparing Effect A Multicenter Study

(2003) Pediatric Cardiology

Complete Heart Block Fetal Management Protocol Review of the Literature and Report of the Smallest Successful Pacemaker Implantation

(2004) Journal of Perinatology

Diagnosis and Management of Restricted or Closed Foramen Ovale in Fetuses with Congenital Heart Disease

(2004) American Journal of Cardiology

Fetal and Neonatal Arrhythmias Association with Maternal Diabetes and Neonatal Macrosomia

(2008) Journal of Perinatology

Impact of Congenital Heart Disease and Surgical Intervention on Neurodevelopment

(2009) Hemodynamics and Cardiology: Neonatal Questions and Controversies

Innovations in Fetal Cardiology Medical and Catheter Intervention Therapy

(2005) Heart Views

Pediatric Academic Society

(2008) Aorta Size Predicts Cerebral Oxygenation in HLHS Neonates: Pediatric Academic Society

Spectrum of Fetal Echocardiographic Findings in Fetuses of Women with Clinical or Serological Evidence of Systemic Lupus Erythematosus

(2008) Journal of Maternal Fetal Medicine

The HeartBrain Interaction in the Fetus Cerebrovascular Blood Flow in the Developing Human

(0001) Progress in Pediatric Cardiology

View publications on PubMed