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Publications

2017

Jaimes R, Swiercz A, Sherman M, Muselimyan N, Marvar P, Posnack, N. Plastics and cardiovascular health: phthalates may disrupt heart rate variability and cardiovascular reactivity. American Journal of Physiology: Heart and Circulatory Physiology. 2017. 313(H1044-1053)

2016

Jaimes R 3rd, Kuzmiak-Glancy S, Brooks DM, Swift LM, Posnack NG, Kay MW. Functional response of the isolated, perfused normoxic heart to pyruvate dehydrogenase activation by dichloroacetate and pyruvate. Pflugers Archive : European journal of physiology. 2016; 468(1):131-42. NIHMSID: NIHMS707102 PubMed [journal] PMID: 26142699, PMCID: PMC4701640

2015

Karabekian Z, Ding H, Stybayeva G, Ivanova I, Muselimyan N, Haque A, Toma I, Posnack NG, Revzin A, Leitenberg D, Laflamme MA, Sarvazyan N. HLA Class I Depleted hESC as a Source of Hypoimmunogenic Cells for Tissue Engineering Applications. Tissue engineering. Part A. 2015; 21(19-20):2559-71. PubMed [journal] PMID: 26218149, PMCID: PMC4605353

Karabekian Z, Idrees S, Ding H, Jamshidi A, Posnack NG, Sarvazyan N. Downregulation of beta-microglobulin to diminish T-lymphocyte lysis of non-syngeneic cell sources of engineered heart tissue constructs. Biomedical materials (Bristol, England). 2015; 10(3):034101. PubMed [journal] PMID: 25775354

Posnack NG, Brooks D, Chandra A, Jaimes R, Sarvazyan N, Kay M. Physiological response of cardiac tissue to bisphenol A: alterations in ventricular pressure and contractility. American journal of physiology. Heart and circulatory physiology. 2015; 309(2):H267-75. PubMed [journal] PMID: 25980024, PMCID: PMC4504967

Posnack NG, Idrees R, Ding H, Jaimes R 3rd, Stybayeva G, Karabekian Z, Laflamme MA, Sarvazyan N. Exposure to phthalates affects calcium handling and intercellular connectivity of human stem cell-derived cardiomyocytes. PloS one. 2015; 10(3):e0121927. PubMed [journal] PMID: 25799571, PMCID: PMC4370601

Wengrowski AM, Wang X, Tapa S, Posnack NG, Mendelowitz D, Kay MW. Optogenetic release of norepinephrine from cardiac sympathetic neurons alters mechanical and electrical function. Cardiovascular research. 2015; 105(2):143-50. PubMed [journal] PMID: 25514932, PMCID: PMC4351353

2014

Posnack NG. The adverse cardiac effects of Di(2-ethylhexyl)phthalate and Bisphenol A. Cardiovascular toxicology. 2014; 14(4):339-57. NIHMSID: NIHMS594272 PubMed [journal] PMID: 24811950, PMCID: PMC4213213

Posnack NG, Jaimes R 3rd, Asfour H, Swift LM, Wengrowski AM, Sarvazyan N, Kay MW. Bisphenol A exposure and cardiac electrical conduction in excised rat hearts. Environmental health perspectives. 2014; 122(4):384-90. PubMed [journal] PMID: 24487307, PMCID: PMC3984226

2012

Posnack NG, Swift LM, Kay MW, Lee NH, Sarvazyan N. Phthalate exposure changes the metabolic profile of cardiac muscle cells. Environmental health perspectives. 2012; 120(9):1243-51. PubMed [journal] PMID: 22672789, PMCID: PMC3440133

Swift LM, Asfour H, Posnack NG, Arutunyan A, Kay MW, Sarvazyan N. Properties of blebbistatin for cardiac optical mapping and other imaging applications. Pflugers Archiv : European journal of physiology. 2012; 464(5):503-12. NIHMSID: NIHMS444754 PubMed [journal] PMID: 22990759, PMCID: PMC3586237

2011

Karabekian Z, Posnack NG, Sarvazyan N. Immunological barriers to stem-cell based cardiac repair. Stem cell reviews. 2011; 7(2):315-25. NIHMSID: NIHMS261276 PubMed [journal] PMID: 21086071, PMCID: PMC3073044
Posnack NG, Lee NH, Brown R, Sarvazyan N. Gene expression profiling of DEHP-treated cardiomyocytes reveals potential causes of phthalate arrhythmogenicity. Toxicology. 2011; 279(1-3):54-64. NIHMSID: NIHMS242251 PubMed [journal] PMID: 20920545, PMCID: PMC3003946

2009

Gillum N, Sarvazyan N. Adhesion proteins, stem cells, and arrhythmogenesis. Cardiovascular toxicology. 2008; 8(1):1-13. NIHMSID: NIHMS45300 PubMed [journal] PMID: 18176845, PMCID: PMC3018288

Gillum N, Karabekian Z, Swift LM, Brown RP, Kay MW, Sarvazyan N. Clinically relevant concentrations of di (2-ethylhexyl) phthalate (DEHP) uncouple cardiac syncytium. Toxicology and applied pharmacology. 2009; 236(1):25-38. NIHMSID: NIHMS93240 PubMed [journal] PMID: 19344669, PMCID: PMC2670944

Karabekian Z, Gillum ND, Wong EW, Sarvazyan N. Effects of N-cadherin overexpression on the adhesion properties of embryonic stem cells. Cell adhesion & migration. 2009; 3(3):305-10. PubMed [journal] PMID: 19377287, PMCID: PMC2712817

2008

Bakunts K, Gillum N, Karabekian Z, Sarvazyan N. Formation of cardiac fibers in Matrigel matrix. BioTechniques. 2008; 44(3):341-8. NIHMSID: NIHMS45304 PubMed [journal] PMID: 18361788, PMCID: PMC3018284