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The Children's Research Institute

The Collaborative Pediatric Critical Care Research Network CPCCRN

This network was initially funded by the National Institutes of Health in 2005 to investigate the safety and efficacy of treatments, management strategies and outcomes of critically ill children in intensive care units. The network consists of seven clinical sites and a data coordinating center. The Collaborative Pediatric Critical Care Research Network (CPCCRN) has completed six observational studies on diverse subjects including cortisol response in critical illness, near-fatal asthma, and opioid tolerance, as well as a randomized controlled trial (CRISIS) of metoclopramide, glutamine, zinc, and selenium to prevent nosocomial infection in critically-ill children. 

Additional studies include interventions to reduce pathologic grief in parents after the death of a critically ill child, development of a functional outcome predictors from critical care, and development of decision support tools for mechanical ventilation. In collaboration with the Pediatric Emergency Care Applied Research Network (PECARN) and the National Heart, Lung and Blood Institute, CPCCRN is conducting a randomized trial of therapeutic hypothermia after pediatric cardiac arrest, titled THAPCA.

Faculty members of the Collaborative Pediatric Critical Care Research Network (CPCCRN):