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The Children's Research Institute


The Division of Rheumatology is a member of the Pediatric Rheumatology Collaborative Study Group (PRCSG) and the Childhood Arthritis and Rheumatism Research Alliance (CARRA), which are the premier research organizations in pediatric rheumatology. Through these groups, the division is actively involved in National Institutes of Health and industry sponsored clinical studies of juvenile arthritis, lupus, dermatomyositis, and vasculitis. Ongoing collaboration with the NIH autoimmunity groups in research and fellowship training further strengthens our efforts toward truly translational research in our field.

Clinical research members:

Representative publications:

Schanberg LE, Sandborg C, Barnhart HX, Ardoin SP, Yow E, Evans GW,Mieszkalski KL, Ilowite NT, Eberhard A, Imundo LF, Kimura Y, von Scheven E, Silverman E, Bowyer SL, Punaro L, Singer NG, Sherry DD, McCurdy D, Klein-Gitelman MD, Wallace C, Silver R, Wagner-Weiner L, Higgins GC, BrunnerHIJung L, Soep JB, Reed A, Provenzale J for the APPLE investigators.  Use of atorvastatin in systemic lupus erythematosus (SLE) in children and adolescents. Arthritis Rheum 2012;64:285-96.

Uribe AG, Huber AM, Kim S, O’Neil KM, Imundo LF,  Jung L,  Kingsbury  DJ,  Klein-Gitelman M,  Lawson EF,  Li SC,  Lovell DJ, Mason T, McCurdy D,  Myones BL, Nassi  L, Rabinovich E, Reiff A, Rosenkranz  M, Schikler KN, Singer NG,  Spalding S, Stevens AM, Cabral DA.  Increased sensitivity of the European Medicines Agency algorithm for the classification of childhood Granulomatosis with Polyangiitis (Wegener granulomatosis).  J Rheumatol 2012;39:1687-97.

Raiji VR, Miller MM, Jung LK. Uveitis in blau syndrome from a de novo mutation of NOD2/CARD15 gene.  J AAPOS  2011;15:205-7.

Ardoin SP, Schanberg LE, Sandborg C, Yow E, Barnhart HX, Mieszkalski2, KL, Ilowite NT, von Scheven ES, Eberhard A, Levy DM, Kimura YK, Silverman E, Bowyer SL, Punaro L, Singer NG, Sherry DD,  McCurdy D,  Klein-Gitelman M, Wallace C , Silver R, Wagner-Weiner L, Higgins GC, Brunner HI, Jung LK, Soep JB, Reed A for the APPLE Investigators. Laboratory markers of cardiovascular risk in pediatric SLE: The APPLE baseline cohort. Lupus 2010;19:1315-25.

Rider LG , Wu L, Mamyrova G, Targoff IN, Miller FW, for the Childhood Myositis Heterogeneity Collaborative Study Group.  Environmental factors preceding illness onset differ in phenotypes of the juvenile idiopathic inflammatory myopathies.  Rheumatology 2010;49:2381-90.

Ruperto N, Lovell DJ, Li T,  Sztajnbok F,  Goldenstein-Schainberg C,  Scheinberg M, Penades IC, Fischbach M, Orozco J, Hashkes  PJ, Hom C, Jung L, Lepore L, Oliveira S, Wallace C, Alessio M, Meunier BB, Cortis E, Eberhard A, Simonini G, Lemelle I, Olson N, Chalom E, Sigal L, Block, A, Covucci A, Nys M, Martini A, Giannini EH for the Paediatric Rheumatology International Trials Organization (PRINTO) and the Pediatric Rheumatology Collaborative Study Group (PRCSG).  Abatacept improves health-related quality of life, pain, sleep quality and daily participation in subjects with juvenile idiopathic arthritis. Arthritis Care Res 2010;11:1542-45.

Ronis T, Duffy CM, Duffy KNW. Galactorrhea associated with juvenile systemic lupus erythematosus: A review of the role of prolactin. Pediatr Rheumatol Online J 2009;7:17.

Schanberg LE, Sandborg C, Barnhart HX, Ardoin SP, Yow E, Evans GE, Mieszkalski KE, Ilowite N, Eberhard A, Levy DM, Kimura Y , von Scheven E, Silverman E, Bowyer SL, Punaro L, Singer NG, Sherry DD, McCurdy D, Klein-Gitelman M, Wallace C, Silver R, Wagner-Weiner L,  Higgins GC, Brunner HI,Jung L, Soep JB, Reed A.  Premature atherosclerosis in pediatric systemic lupus erythematosus: Risk factors for increased carotid intima-media thickness in the atherosclerosis prevention in pediatric lupus erythematosus cohort. Arth Rheum 2009;60:1496-1507.

Lovell DJ, Ruperto N, Goodman S, Reiff A, Jung L, Jarosova K, Nemcova D, Mouy R, Sandborg C, Bohnsack J, Elewaut D, Foeldvari I, Gerloni V, Rovensky J, Minden K, Vehe RK, Weiner LW, Horneff G, Huppertz HI, Olson NY, Medich JR, Carcereri-De-Prati R, McIlraith MJ, Giannini EH, Martini A; Pediatric Rheumatology Collaborative Study Group; Pediatric Rheumatology International Trials Organisation.  Adalimumab with or without methotrexate in juvenile rheumatoid arthritis. N Engl J Med 2008;359:810-20.

Ruperto N, Lovell DJ,Quartier P, Paz E, Pérez N,Silva CA, Mendoza CA, Burgos-Vargas R, Gerloni V,  Melo-Gomes JA, Saad-Magalhães C, Sztajnbok F, Schainber C, Scheinberg M, Penades I, Fischbach M,  Orozco J, Hashkes P, Hom C, Jung LK, Oliveira C, Wallace C, Sigal LH, Block AJ, Sinisi SE, Bonness V, Martini A, Giannini EH.  Abatacept in children with juvenile idiopathic arthritis: A randomized, double-blind, placebo-controlled withdrawal trial.Lancet 2008;372:383-91.

Hossain A, Jung LKL.  Expression of bone-specific alkaline phosphatase on human B cells. Cellular Immunol 2008;253:66-70.

Akhter  MP,  Jung LKL.  Decreased bone strength in HLA-B27 transgenic rat model of spondyloarthropathy.  Rheumatology 2007;46:1258-62. 

Silverman E, Mouy R, Spiegel L, Jung LKL, Saurenmann RK, Lahdenne P, Horneff G, Calvo I, Szer IS, Simpson K, Stewart JA, Strand V. Leflunomide or methotrexate for juvenile rheumatoid arthritis.  N Engl J Med 2005;352:1655-66.

Peterson KD, Attard TM, Jung L, Gulizia JM.  Inflammatory polyps with EBV-related lymphoproliferative disease in a child IPEX syndrome. J Pediatr Gastroenterol  Nutr  2005;41:535-6.

Hajoui O, Janani R, Tulic M, Joubert P, Ronis T, Hamid Q, Zheng H, Mazer BD. Synthesis of IL-13 by human B lymphocytes: regulation and role in IgE production. J Allergy Clin Immunol 2004;114:657-63.