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The Children's Research Institute

Blood Marrow Transplantation

Dr. Jacobsohn’s interest is graft-versus-host disease (GVHD), the main complication after bone marrow transplantation. One of the main barriers has been to develop effective therapy for GVHD as well as effective ways to diagnose and grade GVHD. Dr. Jacobsohn has led and designed a number of clinical trials looking at various therapeutic agents to treat GVHD. Furthermore, he conducts risk factor analyses to look at prognostic factors that affect outcomes of patients after having developed GVHD.

Faculty with interests in Bone Marrow Transplation include:

Representative publications:

Jacobsohn DA, Kurland BF, Pidala J, Inamoto Y, Chai X, Palmer JM, Arai S, Arora M, Jagasia M, Cutler C, Weisdorf D, Martin PJ, Pavletic SZ, Vogelsang G, Lee SJ, Flowers ME. Correlation between NIH composite skin score, patient-reported skin score, and outcome: results from the Chronic GVHD Consortium. Blood 2012 Sep 27;120(13):2545-52, quiz 2774. Epub 2012 Jul 6.

Grkovic L, Baird K, Steinberg SM, Williams KM, Pulanic D, Cowen EW, Mitchell SA, Hakim FT, Martires KJ, Avila DN, Taylor TN, Salit RB, Rowley SD, Zhang D, Fowler DH, Bishop MR, Gress RE, Pavletic SZ. Clinical laboratory markers of inflammation as determinants of chronic graft-versus-host disease activity and NIH global severity. Leukemia 2012 Apr;26(4):633-43. doi: 10.1038/leu.2011.254. Epub 2011 Oct 18.

Loechelt BJ, Boulware D, Green M, Baden LR, Gottlieb P, Krause-Steinrauf H, Weinberg A; for the Type I Diabetes TrialNet Daclizumab/Mycophenolic Acid Study Group. Epstein Barr and other herpes virus infections in early onset type I diabetics treated with Daclizumab and Mycophenolate Mofetil. Clin Infect Dis 2012 Oct 5. [Epub ahead of print]

Kasow KA, Morales-Tirado VM, Wichlan D, Shurtleff SA, Abraham A, Persons DA, Riberdy JM. Therapeutic in vivo selection of thymic-derived natural T regulatory cells following non-myeloablative hematopoietic stem cell transplant for IPEX. Clin Immunol 2011 Nov;141(2):169-76. doi: 10.1016/j.clim.2011.07.005. Epub 2011 Aug 2.

Dubrovsky L, Wong EC, Perez-Albuerne E, Loechelt B, Kamani N, Sande J, Mintz K, Paul W, Luban NL, Rood BR, Fry T. CD34⁺ collection efficiency as a function of blood volumes processed in pediatric autologous peripheral blood stem cell collection. J Clin Apher 2011;26(3):131-7. doi: 10.1002/jca.20281. Epub 2011 Feb 3.

Jacobsohn DA, Arora M, Klein JP, Hassebroek A, Flowers ME, Cutler CS, Urbano-Ispizua A, Bolwell BJ, Antin JH, Boyiadzis M, Cahn JY, Cairo MS, Herzig RH, Isola LM, Klumpp TR, Lee SJ, Petersdorf EW, Santarone S, Gale RP, Schouten HC, Spellman SR, Weisdorf DJ, Wingard JR, Horowitz MM, Pavletic SZ.

Risk factors associated with increased nonrelapse mortality and with poor overall survival in children with chronic graft-versus-host disease. Blood 2011 Oct 20;118(16):4472-9. doi: 10.1182/blood-2011-04-349068. Epub 2011 Aug 30.

Martires KJ, Baird K, Steinberg SM, Grkovic L, Joe GO, Williams KM, Mitchell SA, Datiles M, Hakim FT, Pavletic SZ, Cowen EW. Sclerotic-type chronic GVHD of the skin: clinical risk factors, laboratory markers, and burden of disease. Blood 2011 Oct 13;118(15):4250-7. doi: 10.1182/blood-2011-04-350249. Epub 2011 Jul 26.

Norman BC, Jacobsohn DA, Williams KM, Au BK, Au MA, Lee SJ, Moravec CK, Chien JW. Fluticasone, azithromycin and montelukast therapy in reducing corticosteroid exposure in bronchiolitis obliterans syndrome after allogeneic hematopoietic SCT: a case series of eight patients. Bone Marrow Transplant 2011 Oct;46(10):1369-73. doi: 10.1038/bmt.2010.311. Epub 2010 Dec 6.

Jacobsohn DA, Gilman AL, Rademaker A, Browning B, Grimley M, Lehmann L, Nemecek ER, Thormann K, Schultz KR, Vogelsang GB. Evaluation of pentostatin in corticosteroid-refractory chronic graft-versus-host disease in children: a Pediatric Blood and Marrow Transplant Consortium study. Blood 2009 Nov 12;114(20):4354-60. Epub 2009 Sep 10.

Williams KM, Chien JW, Gladwin MT, Pavletic SZ. Bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation. JAMA 2009 Jul 15;302(3):306-14.

Jacobsohn DA, Tse WT, Chaleff S, Rademaker A, Duerst R, Olszewski M, Huang W, Chou PM, Kletzel M. High WT1 gene expression before haematopoietic stem cell transplant in children with acute myeloid leukaemia predicts poor event-free survival. Br J Haematol 2009 Sep;146(6):669-74. Epub 2009 Jul 23.

Williams KM, Lucas PJ, Bare CV, Wang J, Chu YW, Tayler E, Kapoor V, Gress RE. CCL25 increases thymopoiesis after androgen withdrawal. Blood 2008 Oct 15;112(8):3255-63. Epub 2008 Aug 11.

Perez-Albuerne ED, Eapen M, Klein J, Gross TJ, Lipton JM, Baker KS, Woolfrey A, Kamani N. Outcome of unrelated donor stem cell transplantation for children with severe aplastic anemia. Br J Haematol 2008 Apr;141(2):216-23. Epub 2008 Feb 26.

Gross TG, Loechelt BJ. Epstein-Barr virus associated disease following blood or marrow transplant.

Pediatr Transplant 2003;7 Suppl 3:44-50.