Dr. Zhe Han is an Associate Professor in the Center for Genetic Medicine Research at the Children’s Research Institute. As a Principal Investigator of an NIH-funded laboratory at the main campus of Children’s National Medical Center, Dr. Han leads the efforts of using a simple model system to study the genetic basis of heart, kidney and blood diseases, and to identify therapeutic targets for these diseases.
Dr. Han received his PhD from the University of Michigan in 2002. He then did his postdoc training at the University of Texas Southwestern Medical Center at Dallas. He joined the University of Michigan Medical School as an Assistant Professor to start his independent laboratory in 2006 and moved to Children’s National in 2014 as an Associate Professor. The research focus of Dr. Han’s laboratory is the genetic basis of congenital heart disease, glomerular kidney diseases, and leukemia, using Drosophila as a primary model system. Dr. Han’s group performed a large-scale genetic screen to identify new genes and genetic pathways involved in heart development. His group generates Drosophila models of congenital heart diseases based on human patient genomic sequencing. Dr. Han’s group also discovered that part of the Drosophila heart functions as the filtration kidney, and established the first Drosophila model for glomerular kidney diseases. His group recently developed various Drosophila leukemia models and is establishing a drug screen platform to identify new drugs for leukemia.