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Jeffrey Stuart Dome, MD, PhD

The Center for Cancer and Blood Disorders

Division Chief, Oncology
Division Chief, Hematology

Solid Tumor Program

Children’s Research Institute (CRI)
Center for Cancer and Immunology Research
View CRI Profile for Jeffrey Stuart Dome
Specialties: Renal Tumors

Board CertificationsAmerican Board of Pediatrics/Hematology-Oncology
National Provider Identifier1902809197

Service LocationsChildren's National Medical Center - Sheikh Zayed Campus for Advanced Children's Medicine
111 Michigan Avenue, NW
Washington, DC 20010
Map | Driving Directions

Phone: 202-476-5000

Jeffrey Stuart Dome, MD, PhD, is chief of the Division of Oncology.

Dr. Dome specializes in pediatric solid tumors, with an emphasis on Wilms tumors and other pediatric kidney tumors. As chair of the Renal Tumor Committee for the Children's Oncology Group (COG), Dr. Dome oversees clinical trials for Wilms tumors and other childhood kidney cancers in more than 200 children's hospitals. He has authored more than 30 articles and textbook chapters on pediatric kidney tumors.

Dr. Dome lives in Maryland with his wife, son, and daughter.
TypeSchoolLocationDegreeField of StudyYears
Undergraduate Education University of Pennsylvania Philadelphia, PABachelor of Arts 1983 -1987
Medical School University of Pennsylvania School of Medicine Philadelphia, PADoctor of Medicine 1987 -1991
National & International Recognitions
Giulio D'Angio AwardInternational Conference on the Molecular and Clinical Genetics of Childhood Renal Tumors1999
Young Investigator AwardAmerican Society of Clinical Oncology1997

Affiliations and Memberships
TitleInstitutionCommittee / SectionYears
ChairmanChildren's Oncology GroupRenal Tumor Committee2006 - 2009
ChairmanChildren's Oncology GroupRenal Tumor Biology Committee2002 - 2006
TitleStudy NameInstitutionYears
Principal InvestigatorA phase II study of topotecan for recurrent Wilms tumorGlaxo Smith Kline2005 - 2007
Principal InvestigatorTelomerase as a prognostic indicator for Wilms tumorNational Cancer Institute2000 - 2005
Read more about the research interests of Jeffrey Stuart Dome
Journal Article, Davidoff AM, Giel DW, Jones DP, Jenkins JJ, Krasin MJ, Hoffer FA, Williams MA, and Dome JS (2008), The feasibility and outcome of nephron-sparing surgery for children with bilateral Wilms tumor: The St. Jude Children’s Research Hospital Experience: 1999-2006, Cancer, 112, 2060-2070.

Journal Article, Metzger MM, Stewart CF, Freeman BB, Billups CA, Hoffer FA, Wu J, Coppes MJ, Grant R, Chintagumpala M, Mullen EA, Alvarado C, Daw NC, and Dome JS (2007), Topotecan is active against Wilms tumor: Results of a multi-institutional phase II study, Journal of Clinical Oncology, 25, 3130-3136.

Journal Article, Tabori U and Dome JS (2007), Telomere biology of pediatric cancer, Cancer Investigation, 25, 197-208.

Journal Article, Dome JS, Cotton CA, Perlman EJ, Breslow NE, Kalapurakal JA, Ritchey ML, Grundy PE, Malogolowkin M, Beckwith JB, Shamberger RC, Haase GM, Coppes MJ, Coccia P, Kletzel M, Macklis R, and Green DM (2006), Treatment of Anaplastic Histology Wilms Tumor: Results from the Fifth National Wilms Tumor Study, Journal of Clinical Oncology, 20, 2352-2358.

Journal Article, Tomlinson GE, Breslow NE, Dome J, Guthrie KA, Norkool P, Li S, Thomas P, Beckwith JB, D’Angio GJ, and Green DM (2005), Age at diagnosis as a prognostic factor for rhabdoid tumor of the kidney: A report from the National Wilms Tumor Study Group, Journal of Clinical Oncology, 23, 7641-7645.

Journal Article, Dome JS, Bockhold CA, Li SM, Baker SD, Green, DM, Perlman EJ, Hill DA, and Breslow NE (2005), High telomerase RNA expression is an adverse prognostic factor for favorable histology Wilms tumor, Journal of Clinical Oncology, 23, 9138-9145.

Journal Article, Bakkenist CJ, Drissi R, Wu J, Kastan MB, and Dome JS (2004), Disappearance of the Telomere dysfunction-induced stress response in fully senescent cells, Cancer Research, 64, 3748-3752.

Journal Article, Sanders RP, Drissi R, Billups CA, Daw NC, Valentine MB, and Dome JS (2004), Telomerase expression predicts unfavorable outcome in osteosarcoma, Journal of Clinical Oncology, 22, 3790-3797.

Journal Article, Dome JS and Coppes, MJ (2002), Recent advances in Wilms tumor genetics, Current Opinion in Pediatrics, 14, 5-11.

Journal Article, Dome JS, Liu T, Krasin M, Lott L, Shearer P, Daw N, Billups CA, and Wilimas JA (2002), Improved survival for patients with recurrent Wilms tumor, Journal of Pediatric Hematology Oncology, 24, 192-198.

For a more comprehensive list of publications for Jeffrey Dome, MD, PhD view the National Library of Medicine’s PubMed online database

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