Research Areas

Gangliosides in Cancer

The researchers in this area have delineated basic mechanisms by which tumor gangliosides modulate the behavior of host cells in the tumor microenvironment. They are now comprehensively determining how ganglioside knockout in these tumor systems affects tumor progression, providing the first unambiguous insights in a genetically controlled and stable system.

Board of Visitor's Personalized Cancer Research Program

This program collect cancer patients’ samples to mind genetic alterations to, identify drugs that may offer cure for patients, identify genetic polymorphism that may affect to therapeutic regimen, and establish personalized cancer models that can be used to identify new drugs for cancer treatments.

Bone Marrow Transplantation

Dr. Jacobsohn’s interest is graft-versus-host disease (GVHD), the main complication after bone marrow transplantation. One of the main barriers has been to develop effective therapy for GVHD as well as effective ways to diagnose and grade GVHD.

Cancer Immunology

Cancer immunology focuses on studying the interaction between the immune system and cancer cells. In particular, our investigators seek to take advantage of the fact that the immune system is capable of recognizing cancer specific antigens. Two avenues are being pursued, one seeking to optimize the patients’ own immune system to recognize and subsequently destroy cancer cells, the other seeks to provide a patient with a new immune system (from a donor) capable of destroying cancer cells.

Children's Oncology Program

The clinical oncology program at Children’s National has 20 faculty members who are engaged in clinical research. The program participates in several research consortia including the Children’s Oncology Group (COG), Pediatric Brain Tumor Consortium (PBTC), Therapeutic Advances in Childhood Leukemia and Lymphoma Consortium (TACL), the Cooperative Ependymoma Research Network (CERN), and the North American Consortium for Histiocytosis.

Immunology and Leukemia Research Programs

Our immunology program emphasizes regulation of inflammation and its relevance to hematopoiesis, innate and adaptive immune responses in cancer and autoimmune diseases. The leukemia research programs emphasis on novel animal models for leukemia and leukemia stem cells. Our researchers not only elucidate fundamental mechanisms in immune responses and leukemia development, but also identify novel therapeutics, and that, in collaboration with the clinical oncology program, are being explored for patient care in investigator-initiated clinical trials.

Hematology and Transfusion Medicine

Investigators are involved in many aspects of hematology research, including optimization of the treatment of patients with clotting disorders, developing new therapies for sickle cell disease, and improving our understanding of immune perturbations associated with blood transfusions.

HIV & Infectious Diseases

Investigators are mainly focused in infectious disease epidemiology, laboratory, and clinical research in HIV/AIDS, and laboratory research in viral myocarditis.