Research Areas

Gangliosides in Cancer

The researchers in this area have delineated basic mechanisms by which tumor gangliosides modulate the behavior of host cells in the tumor microenvironment. They are now comprehensively determining how ganglioside knockout in these tumor systems affects tumor progression, providing the first unambiguous insights in a genetically controlled and stable system.

Cancer Immunology

Cancer immunology focuses on studying the interaction between the immune system and cancer cells. In particular, our investigators seek to take advantage of the fact that the immune system is capable of recognizing cancer specific antigens. Two avenues are being pursued, one seeking to optimize the patients’ own immune system to recognize and subsequently destroy cancer cells, the other seeks to provide a patient with a new immune system (from a donor) capable of destroying cancer cells.

Hematology and Transfusion Medicine

Investigators in this section are involved in many aspects of hematology research, including optimization of the treatment of patients with clotting disorders, developing new therapies for sickle cell disease, and improving our understanding of immune perturbations associated with blood transfusions.

HIV & Infectious Diseases

Investigators in this section are primarily involved in infectious disease epidemiology, laboratory, and clinical research in HIV/AIDS, and laboratory research in viral myocarditis.

Program for Cell Enhancement and Technologies for Immunotherapy

Led by Catherine Bollard, MD, the Program for Cell Enhancement and Technologies for Immunotherapy seeks to understand how we can co-opt the body's own immune system to combat cancer, infections, and disorders of immunity, for example graft-versus host disease (GvHD), autoimmunity and immune deficiency.