Evan P. Nadler, MD
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Children's National Medical Center
Principal Investigator, Systems Biology Initiative, Sheikh Zayed Institute for Pediatric Surgical Innovation
George Washington University
School of Medicine and Health Sciences
Associate Professor, Surgery, Pediatrics, and Integrative Systems Biology
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Contact Information
Children's National Medical Center
Center for Genetic Medicine Research
111 Michigan Avenue, NW
Washington, DC 20010-2970
202-476-2200
enadler@childrensnational.org
Education & Training
| Institution & Location |
Degree |
Year(s) |
Field of Study |
| University of Pennsylvania School of Medicine, Philadelphia, PA |
MD
|
1991-1995 |
Medicine |
| Cornell Medical Center/New York Hospital, New York, NY |
Intern |
1995-1996 |
Surgery |
| Cornell Medical Center/New York Hospital, New York, NY |
Resident
|
1996-2002 |
General Surgery |
| Children's Hospital of Pittsburgh, Pittsburgh, PA |
Fellow |
1998-2000 |
Research Fellowship |
| Children's Hospital of Pittsburgh, Pittsburgh, PA |
Fellow
|
2002-2004 |
Pediatric Surgery |
Research Interests
There are two major projects. The overall goal of the first project is to determine the role of in the TGF- ß in the pathogenesis of biliary atresia. The approach will be to employ different strategies designed to inhibit TGF- ß function and then determine what impact blockade has on the development of the hepatic fibrosis associated with biliary atresia, or on the development of biliary atresia itself. This topic has been the subject of Dr. Nadler’s basic science efforts over the past 5 years.
The second project is an attempt to determine the genetic basis of weight loss surgical outcomes. As a national leader in adolescent weight loss surgery, Dr. Nadler has become convinced that surgical failures have little to do with the patient behavior and more to do with factors that are yet identified. The hypothesis is that genetic variation may be the underlying reason for surgical failures, and that larger genetic contributions to surgical outcomes will be seen in younger populations. Dr. Nadler and his team’s approach will be to perform genome wide array studies of adult surgical cohorts and then use a candidate gene approach to adolescents undergoing weight loss surgery with the candidate genes being those identified in the adult study.
Publications
View a partial list of publications for (Evan Nadler) through the National Library of Medicine's PubMed online database.
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