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Linda Leatherbury, MD
Contact Information
Children's National Medical Center
Center for Genetic Medicine Research (CGMR)
111 Michigan Avenue, NW
Washington, DC 20010-2970
202-476-6029
lleather@childrensnational.org
Education & Training
| Institution & Location |
Degree |
Year(s) |
Field of Study |
| University of Virginia, Charlottesville, VA |
BA |
1974 |
Child Psychology |
| Medical College of Georgia, Augusta, GA |
MD |
1978 |
Medicine |
| Children’s National Medical Center, Washington, DC |
Internship / Residency |
1978-1981 |
Pediatric Resident |
| Children’s National Medical Center, Washington, DC |
|
1981-1985 |
Pediatric Cardiology |
Research Interests
Linda Leatherbury, MD, is an internationally recognized researcher investigating cardiac development and genetic causes of congenital heart disease. She is a professor of Pediatrics and Cardiology at Children’s National Medical Center, George Washington University School of Medicing and Health Sciences, and a physician scientist in the Genetics and Developmental Biology Center at National Heart, Lung, and Blood Institute (NHLBI), NIH. Dr. Leatherbury identifies congenital heart defects caused by a chemical mutagen in mice by state of the art imaging techniques. She develops protocols and mentors fellows to perform mouse fetal echocardiography and a new microscopic reconstruction technique called EFIC to identify phenotypes or specific heart defects in mouse families. After a specific phenotype has been identified, Dr. Cecilia Lo’s NHLBI team determines the genetic cause of the defects. Dr. Leatherbury’s research has recently progressed to a translational and clinical focus on the genes that cause congenital heart defects in children and adults. Since several mouse families have been found to have heterotaxy, congenital heart defects, and ciliary dysfunction associated with specific gene mutations, we are now performing translational research. With approved Children’s National Medical Center and NIH Institutional Review Board (IRB) protocols, Dr. Leatherbury and her team are now studying children and adults with heterotaxy for ciliary dysfunction and their associated gene mutations. It is hypothesized that if these patients have ciliary dyskinesis, then these patients may have a prolonged post operative cardiovascular surgery course secondary to the ciliary dysfunction. Another clinical study is under way with an intramural NHLBI/NIH approved and funded IRB protocol on Ebstein’s Anomaly in Belarus and the Ukraine that is in the collaborative planning stage with these countries’ interested cardiac centers. This study is a “genome wide association study” that looks at a million genetic markers in the individual genome of each study participant and looks for linkage with Ebstein’s Anomaly. A replication study is also planned in the United States .
Clinical Interests
Click here for information about this doctor’s clinical practice, including how to make appointments (where applicable).
Publications
View a partial list of publications for Linda Leatherbury, MD through the National Library of Medicine's PubMed online database.
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