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Kimberly Chapman, MD, PhD - Center for Genetic Medicine Research - Children's Research Institute - Children's National Medical Center
Kimberly Chapman, MD, PhD
Contact Information
Children's National
Medical Center
Center
for Genetic Medicine Research (CGMR)
111 Michigan
Avenue, NW
Washington,
DC 20010-2970
202-476-5000
kchapman@childrensnational.org
Education & Training
| Institution &
Location |
Degree |
Year(s) |
Field of Study |
St. Louis University,
St. Louis, MO
|
BS
|
1995
|
Chemistry
|
St.
Louis University,
St. Louis, MO
|
BA
|
1995 |
Biology
|
University of Nebraska, Omaha, NE
|
PhD
|
2000
|
Biochemistry/Molecular Biology
|
University
of Nebraska Medical Center,
Omaha, NE
|
MD
|
2002
|
|
University of Pittsburgh, Pittsburgh, PA
|
Intern
|
2002 -
2003
|
Medicine/Pediatrics
|
| University
of Pittsburgh, Pittsburgh, PA
|
Resident
|
2003
-
2006
|
Medicine/Pediatrics
|
Children's Hospital of Philadelphia,
Philadelphia, PA
|
Fellow
|
2006 -
2010
|
Clinical Genetics/Clinical Biochemical Genetics
|
Research Interests
Dr. Chapman studies
the response to stress initiated by a block at metabolic enzymes that
cause inborn errors of metabolism (IEM). People with IEM are exposed to
exogenous stress (low calories, high protein diet, anxiety, cold
weather, illness) and endogenous stress (the blockade at a particular
enzyme) and each of their cells responds with a cascade of events to
maintain equilibrium and promote survival. Dr. Chapman studies whether
these responses cause secondary pathophysiology leading to the
differing phenotypes seen in patients.
Dr. Chapman's lab has examined cell lines from patients with IEM and
has identified the expression responses in cell lines from patients
with Propionic Acidemia. Using a model of increasing cellular stress to
further perturb these responses, the implications of a biochemical
enzyme block is compared to the responses of “presumably healthy”
controls. At present Dr. Chapman is identifying the individual
components of responses and their interactions with each other using
computational methods, genetics (using individual genetic variation in
response regulation as a tool) and standard molecular biology
techniques.
Clinical Interests
Click here for more information about
this doctor's clinical
practice, including how to make an appointment.
Publications
View a partial list of publications
for Kimberly Chapman through the National Library of Medicine's PubMed
online
database.
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