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Michael Bukrinsky, MD, PhD - Center for Genetic Medicine Research - Children's Research Institute - Children's National Medical Center
Michael I. Bukrinsky, MD, PhD
 |
Children's National
Medical Center
Principal
Investigator,
Children's Research Institute (CRI), Center
for Genetic Medicine Research (CGMR)
George Washington University
School
of Medicine and Health Sciences
Professor
and Vice Chairman, Department of Microbiology, Immunology &
Tropical Medicine
|
Contact Information
Children's National
Medical Center
Center
for Genetic Medicine Research (CGMR)
111 Michigan
Avenue, NW
Washington,
DC 20010-2970
202-476-5000
mtmmib@gwumc.edu
Education & Training
| Institution &
Location |
Degree |
Year(s) |
Field of Study |
2nd Moscow Medical Institute, Moscow, USSR
|
MD
|
1972 -
1978
|
Biochemistry
|
USSR
Academy of Sciences
|
PhD
|
1980
-
1984 |
Molecular
Biology
|
Research Interests
The main focus of Dr.
Bukrinsky's laboratory is analysis of the effects of HIV infection on
cholesterol metabolism. Specifically, we are interested in the
molecular mechanisms behind the impairment of the activity of ABCA1,
the main cellular cholesterol transporter, by HIV-1 protein Nef. We
also perform a clinical study with HIV-infected subjects, using mass
spectrometry to characterize the longitudinal changes in HDL proteome
that may be related to increased risk of atherosclerosis in these
patients. Another HIV-related project in the lab is analysis of host
cell factors associated with the viral pre-integration complex. These
factors assist or restrict viral reverse transcription and nuclear
import, and may represent new targets for anti-HIV therapeutic
approaches. Finally, a long-term interest of Dr. Bukrinsky's laboratory
is a new pro-inflammatory factor, extracellular cyclophilin, and its
role in various diseases such as lung inflammation, rheumatoid
arthritis, and atherosclerosis. His lab also investigates the molecular
events associated with cyclophilin-induced cell activation and test
anti-cyclophilin drugs as therapeutic approach in inflammatory diseases.
Publications
View a partial list of publications
for Michael Bukrinsky through the National Library of Medicine's PubMed
online
database.
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