Expanding cytotoxic T lymphocytes from umbilical cord blood to target three viruses

What’s known:

Children’s National Health System is the only pediatric hospital in the nation that grows personalized T-cells from naïve cord blood (CB), training these CB-derived cells to simultaneously fight adenovirus, cytomegalovirus, and Epstein-Barr virus to control viral infections after transplantation. Here are a number of the critical steps during that three-month manufacturing process.

Expanding cytotoxic T lymphocytes from umbilical cord blood to target three viruses
Source

Source

“CMV-Specific T-Cells Generated From Naïve T-Cells Recognize Atypical Epitopes and May Be Protective In Vivo.” P.J. Hanley, J. J. Melenhors, S. Nikiforow, P. Scheinberg, J.W. Blaney, G. Demmler-Harrison, C.R. Cruz, S. Lam, R.A. Krance, K.S. Leung, C.A. Martinez, H. Liu, D.C. Douek, H.E. Heslop, C. M. Rooney, E.J. Shpall, A.J. Barrett, J.R. Rodgers, and C.M. Bollard.

Published by Science Translational Medicine on April 29, 2015