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  Training Program - Pediatric Infectious Disease

Description How to Apply Benefits Contracts Length of Training
Infection Connection Blog
The Pediatric Infection Connection Blog provides information regarding current infectious diseases issues of interest and importance to the community. Visit www.pediatricinfectionconnection.org
This program’s goals are to provide well-rounded training for fellows in clinical pediatric infectious diseases, as well as training in clinical or basic science research. Successful completion of our fully-accredited ACGME and ABP program will provide the individual with the necessary qualifications for a position as a Board-Certified Pediatric Infectious Diseases Specialist.

The Infectious Diseases Division provides the full range of comprehensive inpatient and outpatient consultative services for both immunocompetent and immunocompromised patients. Additionally, our Special Immunology Service provides care to our population of HIV-exposed and infected children. The division is closely aligned with both the Clinical Microbiology and Epidemiology / Infection Control Divisions. All fellows obtain clinical training at Children’s National Medical Center, a 283-bed freestanding children's hospital which provides the full range of referral and primary care to children in the Washington DC metropolitan region, with a culturally diverse and international patient population base. The newly completed East Tower (opened November 2007) provides the most modern and updated clinical facilities, including a 54-bed NICU, 45 bed PICU, the region's only Cardiac ICU, Neuro ICU, Level 1 ER / trauma center including biohazard response facility, and specialized units for Heart and Kidney, Surgical, and Oncology and Transplantation services.

Fellows may pursue a wide variety of opportunities for research training in clinical, basic science, epidemiologic and outcomes research. We currently sponsor joint fellowship training programs with the Food and Drug Administration (FDA), Center for Biologics Evaluation and Research (CBER), and Center for Drug Evaluation and Research (CDER). As FDA Medical Officers, fellows gain expertise in regulatory and public health aspects of vaccines (CBER), anti-infective agents and antivirals (CDER). The program also has faculty with international health experience who are available to mentor fellows with international career goals. Fellows wishing to pursue training in basic science research may identify mentors at the National Institutes of Health (NIH), as well as Children's Research Institute (CRI) or George Washington University (GWU). Fellows pursuing clinical research may perform research at Children’s National, CRI, including the nation’s only pediatric institution with an NIH-funded Clinical and Translational Science Institute (CTSI). CRI is fully integrated within Children’s National, facilitating close relationships between investigators and clinicians, and research by physician-scientists, including over 20 K-awardees. Fellows may also elect to earn a Master’s Degree in Public Health or enroll in other graduate level coursework from George Washington University.

Training

The program offers the following training:
  • Diagnostic microbiology using laboratories on site:
    • Microbiology laboratory
    • Clinical virus isolation laboratory
    • Molecular diagnostics
    • Other – Daily rounds with Director of Microbiology Lab and formal Microbiology Elective

  • Program provides training in infection control and hospital epidemiology as:
    • Didactic lectures
    • Hands on experience
    • Infection Control Meetings/Membership

  • Opportunity to fulfill the ABP requirements for scholarly activity is available in the following general areas:
    • Bacteriology/bacterial infections
    • Epidemiology and statistics
    • Infection control/hospital epidemiology
    • Immunizations/Public health
    • Mycology/fungal infections: - through affiliated programs
    • Parasitology/parasitic diseases
    • Virology/viral diseases
    • Antimicrobial agents

  • Research opportunities in the section’s program could be describes as:
    • Basic (bench)
    • Molecular
    • Translational
    • Epidemiologic
    • Clinical
    • International/Public Health
    • Health Services
    • HIV, Basic
    • HIV, Clinical
    • ACTG Site

  • Program provides substantial clinical experiences for trainees in special areas/hosts:
    • HIV
    • Bone marrow transplantation
    • Solid organ/transplantation
    • Travelers/adoptees
    • Congenital immune deficiencies
    • Adults: Minimal - related to adults with congenital heart disease/transplant

  • Documented liaison exists offering opportunities for research experience and the laboratory of investigator(s) who is (are) not faculty of the section.

  • Program offers the opportunity to obtain a Master’s degree in a field such as Public Health, Education, Clinical Sciences, or Epidemiology (assuming appropriate arrangements are made)

  • Graduate school courses are available to trainee (assuming appropriate arrangements are made)

  • Program includes ABP-required core curricula in scholarly activities in didactic lecture course for fellows (includes epidemiology, statistics, research design, and academic careers)
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Selected Faculty Publications

  • DeBiasi RL, Robinson BA, Brown RD, Long C, and Clarke P.  Critical role for death receptor-mediated apoptotic signaling in viral myocarditis.   J. Card. Fail. 2010; 16(11):901-10.
  • Rellosa N, Bloch K, Shane A, DeBiasi RL.  Neurologic Manifestations of Pediatric Novel H1N1 Influenza Infection. Pediatric Infectious Disease Journal.  2010; In press, Aug 31 Epub ahead of publication.
  • Paolino K, Sande J, Perez E, Loechelt B, Jantausch B, Painter W, Fry T and DeBiasi RL.  Eradication of disseminated adenovirus in a BMT recipient with severe graft versus host disease using the novel antiviral agent CMX001. J. Clin. Virol. 2010; In press, Nov 18 Epub ahead of publication
  • DeBiasi RL and Waterman P, reporting authors with Centers for Disease Control and Prevention.  MMWR. Tick-borne encephalitis among US travelers to Europe and Asia --- 2000--2009. 2010; Mar 26; 59(11):335-8.
  • Leyenaar JK, Novosad PM, Ferrer KT, Thahane LK, Mohapi EQ, Schutze GE, Kline MW.  Early Clinical Outcomes in Children Enrolled in Human Immunodeficiency Virus Infection Care and Treatment in Lesotho.  Pediatric Infectious Disease Journal. 2010; 29 (4):340-345.
  • Kim P, Wu Y, Cooper C, Rochester G, Valappil T, Wang Y, Kornegay C,  Nambiar S. Meta-Analysis of a possible signal of increased mortality associated with cefepime use. Pediatric Infectious Disease Journal. 2010; 51(4):381-389
  • Sorbello A, Komo S, Valappil T, Nambiar S. Registration Trials of Antibacterial Drugs for the treatment of nosocomial pneumonia. Pediatric Infectious Disease Journal. 2010; 51(S1):S36–S41.
  • Neely M, Rakhmanina N. “Pharmacokinetic Optimization of Antiretroviral Therapy in Children and Adolescents”. Clin Pharmacokinet. 2010; In press.
  • Rakhmanina NY, van den Anker JN. Efavirenz in the therapy of HIV infection. Expert Opin Drug Metab Toxicol. 2010; 6(1):95-103.
  • Neely MN, Rakhmanina NY. Comment on: Pharmacokinetics and 48 week efficacy of low-dose lopinavir/ritonavir in HIV-infected children. J Antimicrobial Chemotherapy. 2010; 65(4):808-9.
  • Rakhmanina NY, van den Anker JN, Soldin SJ, van Schaik RH, Mordwinkin N, Neely MN. Can Therapeutic Drug Monitoring Improve Pharmacotherapy of HIV Infection in Adolescents? Ther Drug Monit. 2010; 32(3):273-281.
  • Rakhmanina N, van den Anker J. Treating an HIV-infected pediatric patient: an easy task.  Antivir Ther. 2010; 15(3):293-6.
  • Neely M, Rakhmanina N. Pharmacokinetic Optimization of Antiretroviral Therapy in Children and Adolescents. Clin Pharmacokinet in press
  • Song X, Perencevich E, Campos JM, Short BL, Singh, N. Clinical and Economic Impact of Methicillin-Resistant Staphylococcus aureus Colonization or Infection on Neonates in Intensive Care Units. Infect Control Hosp Epidemiol. 2010; 31: 177-182
  • Song X, Cheung S, Klontz K, Short BL, Campos J, Singh N. A Stepwise Approach to Control an Outbreak of Methicillin-Resistant Staphylococcus aureus in Neonatal Intensive Care Unit. Am J Inf Control. 2010; 38:607-611.
  • Milstone AM, Song X, Coffin S, Elward A. Identification and Eradication of Methicillin-Resistant Staphylococcus aureus Colonization in the Neonatal Intensive Care Unit: Results of a National Survey.  Infect Control Hosp Epidemiol. 2010;31(1).
  • Nalini Singh, Co-Author as a member of Healthcare Infection Control Advisory Committee: Guidelines for prevention of Catheter-associated Urinary Tract Infections. Infect Control Hosp Epidemiol. 2010; 31: 319-326
  • Siegel D, Song X, Klontz K, Pastor W, Singh N. Epidemiology of Childhood Tuberculosis: Use and Evaluation of the Pediatric Health Information System to Assess Local and National Incidence. Pediatr Infect Dis J. 2011; in press
  • Hickey P, Cape K, Masouka P, Campos C, Pastor B, Wong E, Singh N. A Local, Regional, and National Assessment of Pediatric Malaria in the United States. Am J Trop Med Hygiene.2011; in press .
  • Ferrnandez G, Zeichner SL. Cell line-dependent variability in HIV activation employing DNMT inhibitors.  Virol J. 2010; 7:266.

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Title(s) of Pediatric Infectious Diseases Fellows' Publications, Presentations or Research Projects

  • FDA-track fellow projects relate to New Drug and Vaccine Application reviews.
  • Change in epidemiology of health-care associated infections in a neonatal intensive care unit. Pediatr Infect Dis J 2002; 21:839-42.
  • Porin variation among clinical isolates of Neisseria gonorrheae over a 10-year period, as determined by por variable region typing. J Infect Dis 2003;187:1213-1222
  • Discordant clearance of Gram positive and Gram negative bacteria in SLPI null mice. Regulation of the tonsil cytokine milieu favors HIV susceptibility. J Leak Boil 2006; 80:1145-55.
  • Analysis of Vancomycin Associated Drug Rash, Eosinophilia, and Systemic Symptoms (DRESS) Syndrome. 48th Interscience Conference of Antimicrobial Agents and Chemotherapy / 46th Infectious Disease Society of America Meeting; 1828, 2008.
  • Moraxella catarrhalis Bacteremia in Children. 48th Interscience Conference of Antimicrobial Agents and Chemotherapy / 46th Infectious Disease Society of America Meeting, 2008.
  • Human Parechovirus-3 Infection:  Emerging Pathogen in Neonatal Sepsis.  Pediatr Infect Dis J. 2009; 28(6):545-547.
  • Linezolid associated neuropathy in children. Ninth Annual St. Jude/PIDS Pediatric Microbial Research Conference; 2010.
  • Lyme Disease. In Berman’s Pediatric Decision Making (5th Edition).  Elsevier. 2010. In press.
  • Eradication of disseminated adenovirus in a BMT recipient with severe graft versus host disease using the novel antiviral agent CMX001. J. Clin. Virol. 2010
  • Regional, and National Assessment of Pediatric Malaria in the United States. Am J Trop Med Hygiene.2011; in press .
  • Neurologic manifestations of pediatric novel H1N1 influenza infection. Pediatr Infect Dis J. 2011.

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Frequently Asked Questions

  • Affiliated hospitals:
    Children's National Medical Center (CNMC)

  • Number of pediatric beds:
    284

  • Fellows accepted each year:
    1-2

  • Training for MD; DO; MD, PhD:
    Yes

  • Funding is ensured for all 3 years:
    Yes for FDA Track, Possible for Basic Science Track

  • Visas accepted:
    J1, H1B (for non-FDA track only)

  • Is completion of pediatric residency training in the U.S. OR Canada a requirement?
    Preferred, but not required

  • Documented liaison exists offering opportunities for research experience and the laboratory of investigator(s) who is (are) not faculty of the section?
    YES

  • Program offers the opportunity to obtain a Master’s degree in other fields?
    YES. The program offers the opportunity to obtain a Master’s degree in Public Health, Education, Clinical Sciences, or Epidemiology (assuming appropriate arrangements are made)

  • Graduate school courses are available to trainee?
    YES, assuming appropriate arrangements are made

  • Program includes ABP-required core curricula in scholarly activities in didactic lecture course for fellows?
    YES, includes epidemiology, statistics, research design, and academic careers

  • Program has an NIH-sponsored training grant?
    NO

  • The Infectious Diseases Service is the primary care provider for HIV-infected children and adolescents?
    YES for outpatient
    NO for inpatient

  • Average number of new outpatient consultations per month?
    40

  • Average number of established outpatient follow-up visits per month?
    100

  • Average number of new inpatient consultations per month?
    85

  • Number of trainees completing program in the last 5 years (2006-2010)?
    5

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Meet the Faculty

 
Training Program Director
Roberta L. DeBiasi, MD


Research interest:
Basic: Viral Pathogenesis, Viral Myocarditis, Novel Antiviral Therapies, Apoptosis, Genomics; Clinical: Encephalitis, Myocarditis

 
Associate Program Director
David Hyun, MD


Research Interest
Translational: MRSA, Epidemiology and Pathogenesis, Antimicrobial Stewardship

 
Chief of Infectious Diseases
Nalini Singh, MD, MPH


Research Interest
Infectious disease, epidemiology, global health and epidemiology, molecular diagnosis of antimicrobial resistant infections

 
Faculty
Joseph Campos, PhD


Research Interest
Microbiology, Secretary of ASM

 
Faculty
Kathy Ferrer MD


Research Interest
Adherence and disclosure in children and adolescents with perinatally acquired HIV infection, global pediatric HIV infection

 
Faculty
Barbara Jantausch, MD


Research Interest
Microbial pathogenesis, UTI, pneumococcal infections, antimicrobial therapeutics

 
Faculty
Natella Rakhmanina, MD PhD

Research Interest

HIV pharmacology, pharmacogenetics of antiretroviral drugs



Faculty
Xiaoyan Song, PhD, MBBS

Research Interest
Epidemiology, Biostatistics



Faculty
Bernhard Wiedermann, MD

Research Interest

Medical Education and Evidence-Based Medicine



Faculty
Steve Zeichner, MD


Research Interest
Basic: Immunology of HIV, Microbiotica and Human Infection



FDA Faculty
Sumathi Nambiar, MD

Research Interest

FDA CDER, Anti-infective Agents and regulatory issues



FDA Faculty
Wellington Sun, MD


Research Interest
FDA, Vaccines, Devices and Regulatory Issues

   
FDA Faculty
Doran Fink, MD


Research Interest
FDA CBER, Vaccines, Devices and Regulatory Issues

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Meet the Fellows

2012 Graduates
  • Paulina Mariki, MD
  • Neil Rellosa, MD
2013 Graduates
  • Sahera Dirajlal-Fargo, DO
  •  Prabha Viswanathan, MD
2014 Graduates
  • Grace Appiah, MD
  • Kimberly Martin, DO

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