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Publications

In Press

Clouchoux C, Limperopoulos C. Novel applications of quantitative MRI to the fetal brain. Pediatric Radiology. 2011. (In Press)

2011

  • Bolduc M, du Plessis AJ, Evans A, Guizard N, Zhang X, Robertson R, Limepropoulos. C Cerebellar malformations alter regional cerebral development. Dev Med Child Neuro 2011 Dec; 53(12): 1128-1134.
  • Ranger M, Johnston C, Limperopoulos C, Rennick JE, du Plessis AJ. Cerebral near infrared spectroscopy as a measure of nociceptive evoked activity in critically ill infants. Pain Res Manag 2011 Sept-Oct; 16(5): 331-6.
  • Bolduc M, du Plessis AJ, Sullivan N, Guizard N, Zhang C, Roberston R, Limperopoulos C. Regional cerebellar volumes predict functional outcome in children with cerebellar malformations. Cerebellum 2011 Sept  7. [Epub ahead of print]
  • Donofrio M, du Plessis AJ, Limperopoulos C. Impact of Congenital Heart Disease on Fetal Brain Development and Injury. Curr Opin Pediatr 2011 Oct; 23(5): 502-11.
  • Bolduc M, Sullivan N, Khwaja O, Barnes K, Robertson R, Limperopoulos C. Spectrum of neurodevelopmental disabilities in young children with cerebellar malformations. Dev Med Child Neurol. 2011 May; 53(5):409-16.
  • Owen M, Shevell MI, Majnemer A, Limperopoulos C. Abnormal brain structure and  function in newborns with complex congenital heart defects prior to open heart  surgery:  A review of the evidence. J Child Neurol. 2011 Jun; 26(6):743-55.
  • Clouchoux C, Guizard N, Hakemez H, Evans AC, du Plessis AJ, Limperopoulos C. Normative  fetal  brain growth by quantitative in vivo magnetic resonance imaging. Am J Obstet Gynecol 2011 Oct 12. [Epub ahead of print]
  • Clouchoux C, Kudelski D, Gholipour A, Warfield SK, Viseur, Bouyssi-Kobar M, Mari JL, Evans AC, du Plessis AJ, Limperopoulos C. Quantitative in-vivo MRI measurement of cortical development in the fetus. Brain Struct Funct. 2011 May 12. [ Epub ahead of print]

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2010

  • Limperopoulos C, Tworetzky W, McElhinney DB, Newburger JW, Brown D, Robertson R, McGrath E, Geva J, Annese D, Dunbar-Masterson C, Trainor B, Laussen PC, du Plessis AJ.  Brain volume and metabolism in fetuses with congenital heart disease: evaluation with quantitative magnetic resonance imaging and spectroscopy. Circulation 2010 Jan 5;121(1):26-33.
  • Limperopoulos C, Chilingaryan G, Guizard N, Robertson RL, du Plessis AJ. Cerebellar injury in the premature infant is associated with impaired growth of specific cerebral regions. Pediatr Res. 2010 Apr 12. 2010.
  • Clouchoux C*, Kudelski D, Bouyssi-Kobar, M, du Plessis A, Evans A, Mari JL, Limperopoulos C. Cortical pattern detection for the developing brain: A 3-D vertex labeling and skeletonization approach. J Med Info & Tech. 2010 Oct; 4:161-166.

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2009

  • Majnemer A, Limperopoulos C, Shevell M, Rohlicek C, Rosenblatt B, Tchervenkov C. A new look at outcomes of infants with congenital heart disease: Lessons learnt from a longitudinal study. Pediatr Neurol. 2009;40(3):197-204.  
  • Bolduc M, Limperopoulos C. Neurodevelopment outcomes in children with cerebellar malformations: A systematic review. Dev Med Child Neurol. 2009; 51(4):256-67.
  • O’Leary H, Grega M, Limperopoulos C, Bassan H, Soul J, Di Salvo D, du Plessis AJ.Transfer gain between blood pressure and cerebral perfusion in premature infants predicts germinal matrix-intraventricular hemorrhage. Pediatrics. 2009;124(1):302-9.
  • Limperopoulos C, Robertson R, Sullivan N, Bassan H, du Plessis AJ.  Cerebellar injury in term infants: risk factors, MRI findings, and outcome. Pediatr Neurol. 2009; 41(1):1-8.
  • Birnbaum R, Limperopoulos C. Non-oral feeding practices for infants in the neonatal intensive care unit. Adv Neonatal Care. 2009: 9(4):180-4.
  • Msall M, Limperopoulos C, Park J. Neuroimaging and Cerebral Palsy in Children. Minerva Pediatrica. 2009 ;61(4):415-24.
  • Poretti A, Limperopoulos C, Roulet-Perez E, Wolf NI, Rauscher C, Prayer D, Muller A, Weissert M, Kotzaeridou U, du Plessis AJ, Huisman T, Boltshauser E. Outcome in children with severe unilateral cerebellar hypoplasia. Dev Med Child Neurol. 2009 Oct 23. [Epub ahead of print]
  • Poretti A, Huisman TA, Cowan FM, Del Giudice E, Jeannet PY, Prayer D, Rutherford MA, du Plessis AJ, Limperopoulos C, Boltshauser E. Cerebellar Clefts: A second series. Neuropediatrics 2009 Oct; 40(5):228-33.

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2008

  • Limperopoulos C, Bassan H, Sullivan N, Robertson R, Janet Soul, Moore, M, Ringer S, Volpe JJ, du Plessis AJ. Positive screening for autism in ex-preterm infants: Prevalence and risk factors. Pediatrics. 2008; 121(4):758-65.
  • Majnemer A, Limperopoulos C, Shevell M, Rohlicek C, Rosenblatt B, Tchervenkov C. Developmental and functional outcomes at school entry in children with congenital heart defects who required early open-heart surgery. Pediatrics.  2008;153(1):55-60.  
  • Majnemer A, Mazer B, Lecker E, Leduc A, Limperopoulos C, Shevell M, Rohlicek C, Rosenblatt B, Tchervenkov C. Patters of use of educational and rehabilitation services at school age for children with congenital heart defects. Cardiol Young.  2008;18(3):288-96.
  • Limperopoulos C, Khwaja O, Robertson R, Robson C, Bassan H, Morsash D, Nemes L, Zaccagnini L, Barnes K, Estroff J, Barnewolt C, Levine D, du Plessis AJ. How accurately does current fetal MRI identify posterior fossa anomalies? Amer J Radiol. 2008;190(6):1637-43.
  • Limperopoulos C, Gauvreau K, O’Leary H, Moore M, Bassan B, Eichenwald E, Ringer S, Di Salvo D, du Plessis AJ. Cerebral hemodynamic changes during intensive care of premature infants. Pediatrics. 2008;122(5):e1006-13.

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Invited Review, Chapters, and Editorials

  • Limperopoulos C. The cerebellum and development. In Clinical and Scientific Aspects of Neurodevelopmental Disabilities. International Review of Child Neurology Series. Shevell M (Ed). Mac Keith Press, in press.
  • Majnemer A, Limperopoulos C. Outcomes in childhood disability. In Clinical and Scientific Aspects of Neurodevelopmental Disabilities. International Review of Child Neurology Series. Shevell M (Ed). Mac Keith Press, in press.
  • Limperopoulos C, du Plessis AJ. Disorders of Cerebellar Growth and Development. Current Opinions in Pediatrics. Pomeroy S (Ed). Lippincott, Williams & Wilkins. 18(6): 621-627, 2006.      
  • Limperopoulos C. Injury to the developing cerebellum: Mechanisms and consequences. Amiel-Tison C (Ed). NeoReviews. 8(10), 2007.
  • Limperopoulos C, du Plessis AJ.  Neurological Complications of Congenital heart Disease and Cardiac Surgery in Children. Neurology and General Medicine 4th Edition. Aminoff MJ (Ed). Elsevier, 2008.
  • Limperopoulos C and Clouchoux C*.  Advancing Fetal MRI: Targets for the Future. Seminars in  Perinatology,  33(4):289-98, 2009.
  • Limperopoulos C. Disorders of the Fetal Circulation and The Fetal Brain. Clinics in Perinatology, 36(3):561-77, 2009.
  • Limperopoulos C. Neonatal Brain Injury and Autistic Spectrum Disorders in Survivors. In Clinics in Perinatology, 36(4):791-805, 2009.
  • Limperopoulos C. Advanced neuroimaging techniques: their role in the development of future fetal and neonatal neuroprotection. In Seminars in Perinatology 34(1):93-101, 2010.
  • Limperopoulos C. Extreme prematurity, cerebellar injury, and autism. Semin Pediatr Neurol. Mar;17(1):25-9, 2010.
  • Limperopoulos C, Folkerth R, Barnewolt CE, Connolly S, Du Plessis AJ. Posthemorrhagic cerebellar disruption mimicking Dandy-Walker malformation: fetal imaging and neuropathology findings. Semin Pediatr Neurol. Mar;17(1):75-81, 2010.
  • Limperopoulos C. Cerebellar injury in the premature infant. In Clinics in Developmental Medicine, Cerebellar Disorders in Children. Bolsthauser E & Schmahmann J (Eds). MacKeith Press (in press).
  • Limperopoulos C. Neuroimaging Testing. Measures of outcomes and their determinants for children and youth with developmental disabilities. Majnemer A (Ed), Mackeith Press (in press).
  • Limperopoulos C, du Plessis AJ.  Neurologic disorders in children with heart disease.  Chapter 101.  In:  Swaiman KF, Ashwal S, Ferriero DM, Schor NF (eds).  Pediatric Neurology: Principles and Practice.  5th ed.  St. Louis:  Mosby (in press).
  • Limperopoulos C. Fetal Magnetic Resonance Spectroscopy.  MRS in Pediatric Brain Disorders.  Bluml S & Panigrahy A (Eds), Springer (In preparation).
  • Limperopoulos C. Imaging the Fetal Brain. Acquired Brain Injury in the Fetus and Newborn Shevell M (Ed), Mackeith Press (In preparation).

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Abstracts (* denotes trainees)

  • Wu J*, Awate S, Licht D, Avants B, Clouchoux C, du Plessis A, Gee J,  Limperopoulos C. Cortical folding measurement is a potential indicator for prenatal brain maturity. International Conference on Medical Image Computing and Computer Assisted Intervention, Image Analysis of Human Brain Development, September 2011 (Poster).
  • Owen M*, du Plessis AJ, Bouyssi-Kobar M, Clouchoux C,  Limperopoulos C. Impaired brain structure and function in newborns with complex congenital heart disease prior to open heart surgery. Child Neurology Society, October 2011 (Poster).
  • Owen M*, du Plessis AJ, Bouyssi-Kobar M, Clouchoux C,  Limperopoulos C. Relationship between brain structure and function prior to open heart surgery in newborns with complex congenital heart disease. Children’s National Medical Center Research Week, April 2011 (Poster).
  • Clouchoux C*, Kudelski D, Gholipour A, Warfield SK, Viseur S, Mari JL, Evans AC, Du Plessis AJ, Limperopoulos C. In-vivo fetal cortical development. International Society of Magnetic Resonance in Medicine, May 2011 (Platform).
  • Bouyssi-Kobar M*, Concha L, Larcher K, du Plessis AJ, Limperopoulos C. In-Utero Diffusion Tensor Imaging of the Healthy Fetal Brain. Children’s National Medical Center Research Week, April 2011 (Poster).
  • Licht D, Limperopoulos C, du Plessis AJ, Gee JC, Wu J, Dedstrom G, Vossough A. Validation of a Semiquantitative Fetal MRI Brain Maturation Score. Child Neurology Society, October 2010 (Platform).
  • Clouchoux C, Kudelski D, Bouyssi-Kobar M, Viseur S, Du Plessis AJ, Evans AC, Mari JL, Limperopoulos C. “Cortical pattern detection for the developing brain: a 3D vertex labeling and skeletization approach“.15th International Conference on Medical Informatics & Technologies, MIT 2010. Zakopane, Poland October 2010 (Platform).
  • Bouyssi-Kobar M*, Clouchoux C, Guizard N, Limperopoulos C. 4-D In Vivo Fetal MRI Brain Atlas. The Young European Scientist Meeting, Portugal, October 2010 (Platform).
  • Majnemer A, Limperopoulos C, Shevell M, Rohlicek C, Rosenblatt B, Tchervenkov C. Gender differences in the developmental outcomes of children with congenital heard defects who required early open heart surgery. Child Neurology Society Meeting, October 2010 (Poster).
  • Lechpammer ML, Xu G, du Plessis A, Limperopoulos C, Folkerth RD.  Crossed cerebellar ‘atrophy’ following periventricular hemorrhagic infarction in a 9-year old survivor of extreme prematurity. AANP 2010 (Platform).
  • Clouchoux C*, Boyssi-Kobar M, Larcher K, Evans AC, Limperopoulos C. Cerebellar injury impairs cerebral cerebral development in preterm infants”, MUHC Research Day 2010 (Platform).
  • Clouchoux C*, Coupé P, Manjon J, Guizard N, Bouyssi-Kobar M, Lefebvre M,  du Plessis AJ,   Evans AC, Limperopoulos C. “A novel approach for high-resolution image reconstruction for in-vivo fetal brain MRI”, Human Brain Mapping 2010 (Poster).
  • Clouchoux C*, du Plessis AJ, Evans AC, Larcher K, Limperopoulos C. “Remote cerebral cortical effects following injury to the immature Cerebellum”, Human Brain Mapping 2010 (Poster).
  • Limperopoulos C, Sullivan N, Robertson R. du Plessis AJ. Prevalence of autism spectrumdisorders in ex-preterm survivors of cerebellar injury. American Academy of Cerebral Palsy and Developmental Medicine 2010 (Platform).
  • Wu J*, Awate SP, Licht DJ, Limperopoulos C, Gee JC Cortical folding analysis for normal fetuses International Society of Magnetic Resonance in Medicine  2010 (Platform).
  • Limperopoulos C, Wu J, Licht D, Gee JC, Awate AJ, du Plessis AJ. Quantitative MRI measurements of cortical development in the fetus. Society of Pediatric Research 2010 (Plaform).
  • Licht D, Limperopoulos C, du Plessis AJ, Gee JC, Wu J, Dedstrom G, Vossough A. Development of a semi-quantitative fetal brain maturation score on MRI. Society of Pediatric Research 2010 (Poster).
  • Limperopoulos C, du Plessis AJ. Cerebellar injury and autism spectrum disorders in ex-preterm survivors. Society of Pediatric Research 2010 (Poster).
  • Clouchoux C*, Bouyssi-Kobar M, Lefebre M, Evans A, Limperopoulos C. Quantifying cortical development in the living fetus using advanced MRI. Preston Rob Annual Neuroscience Research Day, Montreal Children’s Hospital, 2009 (Platform).
  • Bolduc M*, Guizard N, Evans A, Limperopoulos C. Impact of cereballar malformations on cerebral growth and development using Advanced 3-D volumetric MRI. Preston Robb Annual Neuroscience Research Day, Montreal Children’s Hospital, 2009 (Platform)
  • Poretti A, Huisman TA, Cowan FM, Del Guidice E, Jeannet PY, Prayer D, Rutherford MA, du Plessis AJ, Limperopoulos A, Boltshauer E.  Cerebellar clefts: a second series. 8th Conference of the European Paediatric Neurology Society in Harrogate (UK). European Journal of Paediatric Neurology:13, Supplement 1, page S27.
  • Ranger M*, Johnston C, Limperopoulos C, Rennick J, Withington D, du Plessis A. Description of global cerebral activation during noxious stimulus in critically ill preterm infants (Poster). International Symposium on Pediatric Pain 2009, Acapulco.
  • Guizard N*, Evans A, Lepage C, du Plessis AJ, Limperopoulos C. Automatic     model-based fetal brain parcellation to quantify in vivo fetal brain development  (Platform). Human Brain Mapping     2009, San Francisco.
  • Manjon JV*, Guizard N, Robles M, Evans AC. Limperopoulos C. Fetal MRI slice reconstruction using 3D inpainting (Poster). Human Brain Mapping 2009, San Francisco.
  • Poretti A*, Limperopoulos C, Wolf NI, Roulet-Perez E, Rauscher C, Prayer D, Müller A, Weissert M, Kotzaeridou U, du Plessis AJ, Huisman TA, Boltshauser E Life with only one half of the cerebellum: outcome in children with severe unilateral cerebellar hypoplasia (Poster). Gesellschaft fur Neuropadiatrie 2009, Graz.
  • Bolduc M*, Evans A, Guizard N, Limperopoulos C. Do cereballar malformations in the young child alter cerebral growth and development? (Platform). Preston Robb Annual Neuroscience Research Day. November 2008.
  • Limperopoulos C, Tworetzky W, Newburger JW, Robertson R, Brown D, McElhinney DB, McGrath E, Geva J, Annese D, Dunbar-Masterson C, Trainor B, Laussen PC, du Plessis AJ.   Third-trimester volumetric brain growth is impaired in fetuses with congenital heart disease (Platform). American Heart Association, November 2008.
  • Limperopoulos C, Tworetzky W, Robertson R, Brown D, Newburger JW, McElhinney DB, McGrath E, Geva J, Annese D, Dunbar-Masterson C, Trainor B, Laussen PC, du Plessis AJ.  Impaired brain metabolism in fetuses with congenital heart disease (Platform) American Heart Association, November 2008.
  • Bolduc M*, du Plessis A, Robertson R, Guizard N, Limperopoulos C. Do regional reductions in cereballar volume predict functional disabilities in children with cerebellar malformations? (Platform). American Academy of Cerebral Palsy and Developmental Medicine. September 2008.
  • Bolduc M*, du Plessis A, Robertson R, Guizard N, Limperopoulos C. Structural and Functional Consequences of Cerebellar Malformations on the Developing Child (Platform). McGill University Health Center Institute: Health Outcomes and Public Health and Preventative Medicine Axes, June 2008.
  • Guizard N*, du Plessis AJ, Fonov V, Hakyemez H, Evans A, Limperopoulos C. Development of 3-D Fetal MRI Brain Altas: Clinical Application (Poster). Human Brain Mapping, June 2008.
  • Limperopoulos C, du Plessis A.  Cerebellar injury impairs cerebral growth and development in preterm infants. (Platform). American Academy of Cerebral Palsy and Developmental Medicine. September 2008.
  • Guizard N*, Lepage C, Fonov V, Hakyemez H, Evans A, Limperopoulos C. Development of a Fetal Altas from Multi-axial MR Acquisitions (Platform). International Society for Magnetic Resonance in Medicine, May 2008.


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